Results 81 to 90 of about 344,007 (291)

ANGPTL4 Exacerbates Renal Injury in Diabetic Kidney Disease by Impairing Podocyte Lipophagy via Compromised Lysosomal Degradative Function

Advanced Science, EarlyView.
In diabetic kidney disease, elevated podocyte ANGPTL4 is linked to reduced TFEB nuclear localization and compromised lysosomal degradative function. These changes impair podocyte lipophagy and promote lipid‐droplet accumulation and podocyte injury, which may contribute to renal injury progression.
Xiaojing Liu, Shimin Jiang, Zhenkun Yang, Shunlai Shang, Jiayi Li, Guming Zou, Cheng Zhou, Wenge Li   +7 more
wiley   +1 more source

Intraocular drug delivery systems for Diabetic retinopathy: Current and future prospective [PDF]

BioImpacts
In pharmaceutical research and development, novel drug delivery systems represent a significant advancement aimed at enhancing the efficacy of therapeutic agents through innovative delivery mechanisms.
Sayed Latif Taheri, Safoora Poorirani, Sayed Abolfazl Mostafavi   +2 more
doaj   +1 more source

Association Between Diabetic Retinopathy and Insomnia Risk: A Nationwide Population-Based Study

Frontiers in Endocrinology, 2022
BackgroundPrevious studies have suggested a close link between sleep disturbances and diabetic retinopathy (DR). However, to date, no confirmatory findings have been reported.
Yoo Hyun Um, Tae-Won Kim, Jong-Hyun Jeong, Seung-Chul Hong, Ho-Jun Seo, Kyung-Do Han   +5 more
doaj   +1 more source

Indian Diabetic Retinopathy Image Dataset (IDRiD): A Database for Diabetic Retinopathy Screening Research

International Conference on Data Technologies and Applications, 2018
Diabetic Retinopathy is the most prevalent cause of avoidable vision impairment, mainly affecting the working-age population in the world. Recent research has given a better understanding of the requirement in clinical eye care practice to identify ...
Prasanna Porwal, S. Pachade, Ravi Kamble, M. Kokare, Girish Deshmukh, Vivek Sahasrabuddhe, F. Mériaudeau   +6 more
semanticscholar   +1 more source

Diabetic Retinopathy: An Overview on Mechanisms, Pathophysiology and Pharmacotherapy

Diabetology, 2022
Diabetes mellitus is one of the most frequently occurring metabolic disorders (DMs), impairing healthy life around the globe, with mild-to-severe secondary complications. DM is associated with secondary complications, including diabetic retinopathy (DR),
P. Ansari, Noushin Tabasumma, Nayla Nuren Snigdha, Nawfal Hasan Siam, R. Panduru, S. Azam, J. M. A. Hannan, Y. Abdel-Wahab   +7 more
semanticscholar   +1 more source

Robust detection of microaneurysms for sight threatening retinopathy screening [PDF]

, 2008
Diabetic retinopathy is one of the major causes of blindness. However diabetic retinopathy does not usually cause a loss of sight until it has reached an advanced stage.
Bhalerao, Abhir, Anand, Sarabjot Singh, Pounnusamy Saravanan, Saravanan, Ponnusamy, Amiya Patanaik, Sarabjot Anand, Patanaik, Amiya, Abhir Bhalerao   +7 more
core   +1 more source

Multifunctional Manganese Oxide Nanocomposite Hydrogel With Synergistic Reactive Oxygen Species‐Scavenging, Oxygen‐Generating, Immunomodulatory, and Photothermal Antimicrobial Activities for Enhanced Diabetic Wound Healing

Advanced Science, EarlyView.
CFP/PC@MnO2 hydrogel integrates ROS scavenging, oxygen delivery, oxidative stress reduction, immunomodulation, and photothermal antibacterial properties. The incorporation of PC@MnO2 NPs endows the hydrogel with multiple functional advantages tailored to the pathological microenvironment of diabetic wounds, including efficient ROS clearance, mitigation
Zhi Xu, Xiaodong Luo, Jingxian Wu, Chaoyang Huang, Zhuoying Yang, Yixiang HePeng, Bosong Zhou, Xiang Li, Ruiyuan Liu, Xu Wu   +9 more
wiley   +1 more source

SmartPlus: a computer-based image analysis method to predict continuous-valued vascular abnormality index in Retinopathy of Prematurity

International Journal of Retina and Vitreous
Plus disease is characterized by abnormal changes in retinal vasculature of premature infants. Presence of Plus disease is an important criterion for identifying treatment-requiring cases in Retinopathy of Prematurity (ROP).
Sayed Mehran Sharafi, Nazanin Ebrahimiadib, Ramak Roohipourmoallai, Afsar Dastjani Farahani, Marjan Imani Fooladi, Golnaz Gharehbaghi, Elias Khalili Pour   +6 more
doaj   +1 more source

Pro-Inflammatory diet accounts for higher prevalence of retinopathy in diabetes participants rather than normal glucose and prediabetes: Results from NHANES, 2005–2008

Frontiers in Nutrition, 2023
Retinopathy is a chronic inflammatory disease whose prognosis could be improved with dietary interventions. However, the association between a pro-inflammatory diet and the prevalence of retinopathy has not been fully elucidated.
Wenjun Pan, Zhuqi Zhang, Yuzhuo Zhang, Haining Lu, Baohua Wang, Shaoyang Zhao, Saimei Li   +6 more
doaj   +1 more source

Nano Proton Scavengers Modulate Endosomal pH to Inhibit Microglial Activation and Enhance Stroke Recovery

Advanced Science, EarlyView.
Amphiphilic sulfonated chitosan nanoparticles buffer endo/lysosomal acidity in microglia by limiting V‐ATPase membrane recruitment and restoring endosomal homeostasis. Following systemic administration, they accumulate in the ischemic hemisphere partly through association with infiltrating immune cells, suppress TLR3/IRF3 and TLR4/NF‐κB signaling ...
Xuanlin Wang, Yujing Shi, Zehua Gao, Jing Wang, Changsheng Liu   +4 more
wiley   +1 more source