Results 91 to 100 of about 7,318 (257)

Fifteen Years of PNPLA3: Transforming Hepatology Through Human Genetics

Liver International, Volume 45, Issue 9, September 2025.
ABSTRACT Steatotic liver disease (SLD), caused by excess lipid accumulation in hepatocytes, is now a leading global liver condition triggered by metabolic dysfunction, alcohol, toxins and heritable factors. The main genetic determinant is the common PNPLA3 p.I148M variant, which explains a substantial portion of SLD interindividual and interethnic ...
Stefano Romeo, Luca Valenti
wiley   +1 more source

The effect of retinyl palmitate added to iron-fortified maize porridge on erythrocyte incorporation of iron in African children with vitamin A deficiency [PDF]

, 2017
Retinyl palmitate added to Fe-fortified maize bread has been reported to enhance Fe absorption in adult Venezuelan subjects but not in Western Europeans.
Adou, Pierre, Davidsson, Lena, Hurrell, Richard, Walczyk, Thomas, Zeder, Christophe   +4 more
core  

Rescue of the Stargardt Disease Phenotype in Abca4 Knockout Mice Through Dietary Modulation of the Vitamin A Receptor RBPR2

FASEB BioAdvances, Volume 7, Issue 8, August 2025.
Genetics and the diet attenuate ocular lipofuscin production and accumulation and improves visual and RPE function in Abca4−/− mice. Abca4−/− mice supplemented with β‐carotene (BC) diet showed an increase in BC concentrations and retinoic acid metabolites in the liver, which led to an induction of hepatic Rbpr2 gene activity via RAR and RXR regulatory ...
Rakesh Radhakrishnan, Matthias Leung, Drew Yochim, Heidi Roehrich, Scott W. McPherson, Glenn P. Lobo   +5 more
wiley   +1 more source

Applicability of the Threshold of Toxicological Concern (TTC) approach to cosmetics – preliminary analysis [PDF]

, 2011
This report describes the application of chemoinformatic methods to explore the applicability of the Threshold of Toxicological Concern (TTC) approach to cosmetic ingredients.
CRONIN Mark, ENOCH Steven, FIORAVANZO Elena, FUART GATNIK Mojca, PAVAN Manuela, WORTH Andrew, YANG Chihae   +6 more
core   +1 more source

Can the choice of artificial tears harm patients? A narrative review with an overview of the Nordic market

Acta Ophthalmologica, Volume 103, Issue 5, Page 586-608, August 2025.
Abstract Purpose To provide an overview of artificial tears marketed in the following Nordic countries: Denmark, Finland, Norway, Iceland and Sweden. Furthermore, this review aimed to highlight the different preservatives and other constituents found in artificial tears in the Nordic market, focussing on adverse effects.
K. N. Mikha, C. E. Ø. Rasmussen, S. N. G. Ahrensberg, J. Freiberg, R. A. Wozniak, U. M. K. Alnoor, F. Fineide, T. P. Utheim, S. Heegaard, M. Kolko   +9 more
wiley   +1 more source

Chylomicron remnant-vitamin A metabolism by the human hepatoma cell line HepG2.

Journal of Lipid Research, 1987
The binding and metabolism of [3H]vitamin A-containing chylomicron (CM) remnants by the human hepatoma cell line HepG2 were studied. Mesenteric lymph chylomicrons were collected from [3H]retinol-fed rats and incubated with lipoprotein lipase to obtain CM
C M Lenich, A C Ross
doaj   +1 more source

R91W mutation in Rpe65 leads to milder early-onset retinal dystrophy due to the generation of low levels of 11-cis-retinal [PDF]

, 2017
RPE65 is a retinal pigment epithelial protein essential for the regeneration of 11-cis-retinal, the chromophore of cone and rod visual pigments. Mutations in RPE65 lead to a spectrum of retinal dystrophies ranging from Leber's congenital amaurosis to ...
Grimm, Christian, Oberhauser, Vitus, Remé, Charlotte E., Samardzija, Marijana, Seeliger, Mathias, Tanimoto, Naoyuki, Thiersch, Markus, von Lintig, Johannes, Wenzel, Andreas   +8 more
core  

Lysosomal acid lipase is the major acid retinyl ester hydrolase in cultured human hepatic stellate cells but not essential for retinyl ester degradation

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2020
Vitamin A is stored as retinyl esters (REs) in lipid droplets of hepatic stellate cells (HSCs). To date, two different pathways are known to facilitate the breakdown of REs: (i) Hydrolysis of REs by neutral lipases, and (ii) whole lipid droplet degradation in autolysosomes by acid hydrolysis.
Wagner, Carina, Hois, Victoria, Pajed, Laura, Pusch, Lisa-Maria, Wolinski, Heimo, Trauner, Michael, Zimmermann, Robert, Taschler, Ulrike, Lass, Achim   +8 more
openaire   +2 more sources

Associations of serum carotenoids with cardiovascular disease mortality among patients with metabolic dysfunction‐associated steatotic liver disease

Hepatology Research, Volume 55, Issue 8, Page 1111-1127, August 2025.
In metabolic dysfunction‐associated steatotic liver disease/metabolic dysfunction‐associated steatohepatitis patients aged <60 years, high serum β‐cryptoxanthin concentrations were inversely associated with CVD mortality. Abstract Aim High cardiovascular disease (CVD) mortality occurred among metabolic dysfunction‐associated steatotic liver disease ...
Qian‐Qian Wang, Jing Zhu, Lin‐Jun Miao, Si‐Ang Lv, Guo‐Yin Shen, Jun Wu   +5 more
wiley   +1 more source

Chylomicron remnant cholesteryl esters as the major constituent of very low density lipoproteins in plasma of cholesterol-fed rabbits

Journal of Lipid Research, 1977
Feeding rabbits 500 mg of cholesterol daily for 4 to 15 days greatly increased the concentration of esterified cholesterol in lipoproteins of d < 1.006 g/ml.
A C Ross, D B Zilversmit
doaj   +1 more source