Results 101 to 110 of about 7,318 (257)

Are low tolerable upper intake levels for vitamin a undermining effective food fortification efforts? [PDF]

, 2017
Vitamin A deficiency (VAD) is a major health problem, particularly in low-resource countries, putting an estimated 125-130 million preschool-aged children at increased risk of morbidity and mortality from infectious diseases.
Bloem, Martin W., de Pee, Saskia, Hathcock, John N., Kraemer, Klaus, Moench-Pfanner, Regina, Semba, Richard D., Waelti, Monika   +6 more
core  

Hydroxysteroid 17β‐dehydrogenase 13 (Hsd17b13) knockdown attenuates liver steatosis in high‐fat diet obese mice

Experimental Physiology, Volume 110, Issue 8, Page 1071-1086, 1 August 2025.
Abstract Hydroxysteroid 17β‐dehydrogenase 13 (HSD17B13) loss‐of‐function gene variants are associated with a decreased risk of metabolic dysfunction‐associated steatotic liver disease (MASLD). Our RNA‐seq analysis of steatotic liver from obese mice ± fenretinide treatment identified major beneficial effects of fenretinide on expression of hepatic genes
Shehroz Mahmood, Nicola Morrice, Dawn Thompson, Sara Milanizadeh, Sophie Wilson, Philip D. Whitfield, George D. Mcilroy, Justin J. Rochford, Nimesh Mody   +8 more
wiley   +1 more source

Phenotype of three consanguineous Tunisian families with early-onset retinal degeneration caused by an R91W homozygous mutation in the RPE65 gene [PDF]

, 2018
Purpose: To identify the genetic defect, and to phenotype, three consanguineous Tunisian families presenting with early-onset retinal degeneration (EORD). Methods: All accessible family members were included.
Ambresin, Aude, Arsenijevic, Yvan, Borruat, François‐Xavier, El Matri, Leila, Kawasaki, Aki, Munier, Francis, Schorderet, Daniel, Seeliger, Mathias, Wenzel, Andreas   +8 more
core  

Impact of meal fatty acid composition on postprandial lipaemia, vascular function and blood pressure in postmenopausal women [PDF]

, 2018
Cardiovascular diseases (CVD) are the leading cause of death in women globally, with aging associated with progressive endothelial dysfunction and increased CVD risk.
Bjorkegren, Burdge, Cohn, Hooper, Julie A. Lovegrove, Kim G. Jackson, Kumari M. Rathnayake, Marjoribanks, Michelle Weech, Pokoradi, Schoppen, Westerveld, Windler, Žegura, Žegura   +14 more
core   +1 more source

Effects of dietary retinoid and triglyceride on the lipid composition of rat liver stellate cells and stellate cell lipid droplets

Journal of Lipid Research, 1988
Hepatic stellate cells store the majority of the liver's retinoid (vitamin A) reserves as retinyl esters in stellate cell lipid droplets. A study was conducted to explore the effects of differences in dietary retinoid and triglyceride intake on the ...
H Moriwaki, W S Blaner, R Piantedosi, D S Goodman   +3 more
doaj   +1 more source

PNPLA2 mobilizes retinyl esters from retinosomes and promotes the generation of 11-cis-retinal in the visual cycle. [PDF]

Cell Rep, 2023
Hara M, Wu W, Malechka VV, Takahashi Y, Ma JX, Moiseyev G.   +5 more
europepmc   +1 more source

The mechanisms of Fenretinide-mediated anti-cancer activity and prevention of obesity and type-2 diabetes [PDF]

, 2014
Copyright © 2014. Published by Elsevier Inc. Acknowledgments This work was supported by the British Heart Foundation Intermediate Basic Research Fellowship FS/09/026/27398 to N.M.
McIlroy, George David, Mody, Nimesh
core   +1 more source

Sources and properties of triglyceride-rich lipoproteins containing apoB-48 and apoB-100 in postprandial blood plasma of patients with primary combined hyperlipidemia

Journal of Lipid Research, 2002
Although editing of apolipoprotein (apo)B in the small intestine, yielding apoB-48, is thought to be nearly complete in adult humans, small amounts of intestinal apoB-100 may also be produced. We have evaluated the fraction of unedited apoB secreted from
J. Kovar, R.J. Havel
doaj   +1 more source

Vitamin A, cancer treatment and prevention: The new role of cellular retinol binding proteins [PDF]

, 2015
Retinol and vitamin A derivatives influence cell differentiation, proliferation, and apoptosis and play an important physiologic role in a wide range of biological processes. Retinol is obtained from foods of animal origin.
Agostinelli, S, Arcuri, G, Costanza, G, Doldo, E, Ferlosio, A, Orlandi, A, Passeri, D, Scioli, Mg, Tarquini, C   +8 more
core   +4 more sources

Chylomicron metabolism in an animal model for hyperlipoproteinemia type I

Journal of Lipid Research, 1999
Mink homozygous for the mutation Pro214Leu in lipoprotein lipase (LPL) had only traces of LPL activity but amounts of LPL protein in their tissues similar to those of normal mink.
Roger Savonen, Knut Nordstoga, Björn Christophersen, Anna Lindberg, Yan Shen, Magnus Hultin, Thomas Olivecrona, Gunilla Olivecrona   +7 more
doaj   +1 more source