Results 91 to 100 of about 6,864 (229)

Effect of atorvastatin on postprandial lipoprotein metabolism in hypertriglyceridemic patients

Journal of Lipid Research, 2003
Postprandial lipoprotein metabolism is impaired in hypertriglyceridemia. It is unknown how and to what extent atorvastatin affects postprandial lipoprotein metabolism in hypertriglyceridemic patients.
Klaus G. Parhofer, Ester Laubach, P. Hugh R. Barrett   +2 more
doaj   +1 more source

Applicability of the Threshold of Toxicological Concern (TTC) approach to cosmetics – preliminary analysis [PDF]

, 2011
This report describes the application of chemoinformatic methods to explore the applicability of the Threshold of Toxicological Concern (TTC) approach to cosmetic ingredients.
CRONIN Mark, ENOCH Steven, FIORAVANZO Elena, FUART GATNIK Mojca, PAVAN Manuela, WORTH Andrew, YANG Chihae   +6 more
core   +1 more source

Hydroxysteroid 17β‐dehydrogenase 13 (Hsd17b13) knockdown attenuates liver steatosis in high‐fat diet obese mice

Experimental Physiology, Volume 110, Issue 8, Page 1071-1086, 1 August 2025.
Abstract Hydroxysteroid 17β‐dehydrogenase 13 (HSD17B13) loss‐of‐function gene variants are associated with a decreased risk of metabolic dysfunction‐associated steatotic liver disease (MASLD). Our RNA‐seq analysis of steatotic liver from obese mice ± fenretinide treatment identified major beneficial effects of fenretinide on expression of hepatic genes
Shehroz Mahmood, Nicola Morrice, Dawn Thompson, Sara Milanizadeh, Sophie Wilson, Philip D. Whitfield, George D. Mcilroy, Justin J. Rochford, Nimesh Mody   +8 more
wiley   +1 more source

Investigation of a broad‐spectrum micronutrient formulation as a possible precipitant of pharmacokinetic micronutrient–drug interactions

British Journal of Clinical Pharmacology, Volume 91, Issue 7, Page 1987-1995, July 2025.
Aims Daily broad‐spectrum micronutrients are being used by the general public and formulations are receiving research interest in mental health settings. Despite concerns about combining medicines and broad‐spectrum micronutrients in mental health care, there have not been any formal evaluations of potential interactions.
Bess M. Kew, Matthew P. Doogue, Richard McNeill, Mei Zhang, Julia J. Rucklidge, Christopher M. Frampton, Roger T. Mulder, Ben Beaglehole   +7 more
wiley   +1 more source

Senescence in hepatic stellate cells as a mechanism of liver fibrosis reversal: a putative synergy between retinoic acid and PPAR-gamma signalings [PDF]

, 2016
Hepatic stellate cells (HSCs), also known as perisinusoidal cells, are pericytes found in the perisinusoidal space of the liver. HSCs are the major cell type involved in liver fibrosis, which is the formation of scar tissue in response to liver damage ...
Oben, JA, Panebianco, C, Pazienza, V, Vinciguerra, M   +3 more
core  

Vitamin A and Its Related Diseases

Food Science &Nutrition, Volume 13, Issue 7, July 2025.
Vitamin, an essential micronutrient, is pivotal in human growth, development, immune function, and vision. Deficiency in VA disrupts growth and development in children and increases susceptibility to infectious diseases, such as respiratory and gastrointestinal infections.
Shuhan Rao, Tiewei Li, Xiaojuan Li, Ligong Hou, Wan Sun   +4 more
wiley   +1 more source

Plasma kinetics of vitamin A in humans after a single oral dose of [8,9,19-13C]retinyl palmitate

Journal of Lipid Research, 1996
The kinetics of vitamin A and its major metabolites were investigated in humans. Eleven healthy male subjects ingested 105 mumol (100,000 IU) of [8,9,19-13C]retinyl palmitate in an oily solution.
D V Reinersdorff, E Bush, D J Liberato
doaj   +1 more source

An approach for prioritizing “down-the-drain” chemicals used in the household [PDF]

, 2015
This article has been made available through the Brunel Open Access Publishing Fund.Many chemicals are present in cleaning and personal care products, which after use are washed down the drain and find their way into water bodies, where they may impact ...
Basin, Bolek, Eriksson, Janna, Johnson, Loretz, Loretz, Loretz, Marina Rotsidou, Mark Scrimshaw, Trenholm   +10 more
core   +2 more sources

Germline Disruption of Retinal Pigment Epithelium‐Expressed Zebrafish rlbp1b−/− Results in Selective Dim Light Visual Behavior Deficits and Provides a Screening Platform for Evaluating the Pathogenicity of Human RLBP1 Variants

The FASEB Journal, Volume 39, Issue 12, 30 June 2025.
RLBP1 is a gene that is mutated in several different inherited retinal diseases (IRDs). Here we investigate the consequences of loss of RPE expressed zebrafish Cralbpb using CRISPR knockout models. These consequences include impaired dim light OKR behaviour, altered retinoid profiles, and a disrupted proteomic profile.
John D. Fehilly, Tess McCann, Grace Ruddin, Joanna J. Kaylor, Hannah Grenville, Rebecca Ward, Kieran Wynne, Alicia Gómez Sánchez, Elin Strachan, Gabriel H. Travis, Ross F. Collery, Breandán N. Kennedy   +11 more
wiley   +1 more source

Secretion-recapture process of apolipoprotein E in hepatic uptake of chylomicron remnants in transgenic mice [PDF]

, 1994
To investigate the role of apoE in hepatic uptake of chylomicron remnants, we studied chylomicron metabolism in transgenic mice overexpressing apoE in the liver.
Gotoda T, Harada K, Kawamura M, Namba Y, Ohsuga J, Shimada M, Shimano H, Yamada N, Yamamoto K, Yazaki Y, 山田 信博   +10 more
core   +1 more source