Results 61 to 70 of about 59,959 (160)
Advanced Science, EarlyView.Neuronal activation leads to astrocytic transient volume changes, activating transient receptor potential ankyrin 1 (TRPA1) channels, leading to Ca2+ influx. Activation of TRPA1 causes the release of D‐serine through BEST1. Finally, the augmented extracellular levels of D‐serine boost neuronal activity by binding GluN1‐containing NMDARs, leading to CBV
Kayoung Han +11 more
wiley +1 more source
Retrospective Grid Cells in the Medial Entorhinal Cortex Encode Past Paths During Spatial Navigation
Advanced Science, EarlyView.Retrospective grid cells are identified in the medial entorhinal cortex, with spatial firing patterns that become most grid‐like when activity is projected onto recently traversed locations. Their coding loses spatial precision in darkness and is disrupted during assisted movement, indicating that entorhinal representations incorporate recent path ...
Ruojin Liu +10 more
wiley +1 more source
, 2013 Retro-bølgen, der i de seneste år er skyllet henover de fleste produktkategorier, har givet en række gamle brands en renæssance og nye muligheder for produktdifferentiering.
Hermansen, Judy
core +2 more sources
FUS CLIP-seq identified increased FUS binding in introns flanking cassette exons.
, 2013 A) FUS CLIP assay conditions. B) Western blot analysis of FUS protein immunoprecipitated from FUS CLIP. C) Autoradiography of radiolabeled FUS-RNA complexes from FUS CLIP. Red boxes highlight FUS protein complex regions selected for further analysis.
Geoffrey G. Hicks (14105) +4 more
core +1 more source
Advanced Science, EarlyView.A deep‐learning‐designed binder is fused to a combinatorial degron to create a binder‐degron chimera (bdC) that recruits the CUL2‐RING ubiquitin ligase complex. Encapsulation in a prostate‐cancer‐targeted, CD47‐camouflaged nanocarrier enables tumor‐specific in situ bdC expression, triggering GPX4 degradation and ferroptosis, thereby establishing a ...
Si‐Han Zhang +8 more
wiley +1 more source
Advanced Science, EarlyView.An engineered peptide self‐assembled nanofiber platform, designed to replicate STING–cGAMP binding motifs, facilitates pH‐responsive cytosolic delivery of cGAMP, enhances the endoplasmic reticulum with high efficiency, and robustly activates the STING pathway.
Yubin He +6 more
wiley +1 more source
A Molecularly Defined Midbrain Circuit Mechanism for Sound‐Driven Defensive Behavior and Anxiety
Advanced Science, EarlyView.Schematic diagram showing the Cbln2+ ICx–dPAG circuit for sound‐driven defensive and anxiety‐like behaviors. ABSTRACT The innate defense behaviors in response to threatening sounds play a fundamental role in survival. However, the neural circuits that detect threat‐relevant auditory cues and transform them into defensive behaviors remain poorly defined.
Jie Cao +8 more
wiley +1 more source
The role of FUS in splicing regulation
, 2014 Fused in sarcoma (FUS), also called translocated in liposarcoma (TLS), is a ubiquitously expressed DNA/RNA binding protein belonging to the TET family and predominantly localized in the nucleus.
Ruepp, Marc-David
core
Acoustically Activatable Drug‐Loaded Nanodroplets for Mechanochemical Therapy in Solid Tumors
Advanced Science, EarlyView.Microfluidically fabricated drug‐loaded nanodroplets are sequentially activated by dual‐frequency ultrasound through acoustic droplet vaporization followed by bubble collapse, enabling spatially controlled drug release and mechanical tumor fractionation, resulting in synergistic mechanochemotherapy and prolonged survival.
Tiran Bercovici +4 more
wiley +1 more source
Representasi Gangsing Pada Busana Wanita Retro Playful
, 2018 Munculnya berbagai permainan modern menjadi salah satu faktor penyebab permainan tradisional jarang dimainkan oleh masyarakat. Oleh sebab itu diperlukan upaya untuk melestarikan permainan tradisional sebagai bagian kearifan lokal yang telah menjadi ...
Ni Kadek, Yuni Diantari +2 more
core +2 more sources