Results 41 to 50 of about 59,959 (160)

Early Spatial and Contextual Coding Deficits in Hippocampal CA1 Precede Performance Decline in an Alzheimer's Disease Model

Advanced Science, EarlyView.
Two‐photon calcium imaging in behaving 5xFAD mice reveals early CA1 coding deficits before behavioral decline. Task‐related place cell activity and splitter cell trajectory coding are impaired, with reduced retrospective dominance and greater prospective weighting.
Yimei Li, Mary Ann Go, Hualong Zhang, Robertas Aleksynas, Juliana Kim, Mingyang Gao, Seigfred Prado, Magdalena Sastre, Simon R. Schultz   +8 more
wiley   +1 more source

Retro-Ene Reactions in Acylallene Derivatives

, 2016
Allenic esters and amides 4 undergo a retro-ene reaction to vinylketene (6) and an aldehyde or imine (5) under the conditions of flash vacuum thermolysis (FVT).
Rainer Koch (269263), Curt Wentrup (1433587), Hervé Bibas (3029748)   +2 more
core   +1 more source

Interleukin‐1α Mediates Pancreatic Fibroblast Activation, Regulates Immune Cell Recruitment and Fibrosis in Acute and Chronic Pancreatitis

Advanced Science, EarlyView.
During pancreatitis, IL‐1α is released from necrotic acinar cells. In response to IL‐1α, pancreatic fibroblasts release chemokines and cytokines that regulate the recruitment of immune cells to the damaged organ. Furthermore, IL‐1α primes fibroblasts, resulting in increased tissue fibrosis during chronic pancreatitis.
Hala Mazloum, Shenja Buchholz, Hanna Schifter, Sabine Ameling, Leif Steil, Ben Lewin Becker, Elke Hammer, Georg Homuth, Uwe Völker, Barbara M. Bröker, Lukas Zierke, Frank Ulrich Weiss, Juliane Glaubitz, Matthias Sendler   +13 more
wiley   +1 more source

Mutant FUS induces chromatin reorganization in the hippocampus and alters memory processes

, 2023
International audienceCytoplasmic mislocalization of the nuclear Fused in Sarcoma (FUS) protein is associated to amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD).
Jean-Christophe Cassel, Rafael Alcala-Vida, Dieterlé, Stéphane, Isabel Paiva, Seguin, Jonathan, Jonathan Seguin, Paiva, Isabel, Damien Plassard, Cosquer, Brigitte, Charles Decraene, Megat, Salim, Le Gras, Stéphanie, Decraene, Charles, Alcalá-Vida, Rafael, Dupuis, Luc, Plassard, Damien, Anne-Laurence Boutillier, Brigitte Cosquer, Stéphanie Le Gras, Boutillier, Anne-Laurence, Salim Megat, Tzeplaeff, Laura, Karine Merienne, Cassel, Jean-Christophe, Stéphane Dieterlé, Gina Picchiarelli, Laura Tzeplaeff, Luc Dupuis, Merienne, Karine, Picchiarelli, Gina   +29 more
core   +1 more source

Molecular Glue Degraders Enhance CAPRIN1‐Dependent Lysosomal Degradation of APP and Reduce Amyloid β in Alzheimer's Disease

Advanced Science, EarlyView.
A new class of lysosome‐directed molecular glue degraders selectively enhance CAPRIN1–APP interactions, driving APP degradation and reducing amyloid‐β production in human neurons and Alzheimer's disease mouse models. This CAPRIN1‐dependent targeted protein degradation strategy reveals a previously unrecognized therapeutic approach for disrupting the ...
Sunghan Jung, Xu Wang, Bin Liu, Raktim Roy, Nancy Jaiswal, Ratan K. Rai, Yuichiro Takagi, Cen Gao, Lifan Zeng, Ho‐Yin Lo, Reagan K. Wohlford, Ryan K. Higgins, Bruce T. Lamb, Anantha Shekhar, Anita C. Bellail, Chunhai Hao   +15 more
wiley   +1 more source

Impaired DNA damage response signaling by FUS-NLS mutations leads to neurodegeneration and FUS aggregate formation. [PDF]

, 2018
Amyotrophic lateral sclerosis (ALS) is the most frequent motor neuron disease. Cytoplasmic fused in sarcoma (FUS) aggregates are pathological hallmarks of FUS-ALS.
Troost, D., Weis, J., Pal, A., Stanslowsky, N., Sterneckert, J., Günther, R., Storkebaum, E., Ludolph, A., Petri, S., Hyman, A., Goswami, A., Cordes, N., Freischmidt, A., Pan-Montojo, F., Naujock, M., Reinhardt, P., Frickenhaus, M., Holzmann, K., Grill, S., Japtok, J., Vehlow, A., Wegner, F., Storch, A., Hermann, A., Naumann, M., Weishaupt, J., Lojewski, X., Jin, M., Poser, I., Liebau, S., Boeckers, T.   +30 more
core   +2 more sources

Minor intron splicing is regulated by FUS and affected by ALS-associated FUS mutants [PDF]

, 2016
Fused in sarcoma (FUS) is a ubiquitously expressed RNA-binding protein proposed to function in various RNA metabolic pathways, including transcription regulation, pre-mRNA splicing, RNA transport and microRNA processing.
Martino Colombo, Schweingruber, Christoph, Giuseppe Filosa, Filosa, G., Lenzken, S. C., Stefan Reber, Silvia C Lenzken, Stettler, Jolanda, Mühlemann, Oliver, Jolanda Stettler, Christoph Schweingruber, Lenzken, Silvia C, Filosa, Giuseppe, Jutzi, Daniel, Silvia ML Barabino, Barabino, Silvia Ml, Oliver Mühlemann, Marc‐David Ruepp, Reber, Stefan, Daniel Jutzi, Rémy Bruggmann, Bruggmann, Rémy, Ruepp, Marc-David, Bachi, Angela, Colombo, Martino, Barabino, S. M., Ruepp, Marc‐David; id_orcid, Bachi, A., Angela Bachi, Jutzi, D., Barabino SM, Bachi A, Ruepp MD, Filosa G, Bruggmann R, Lenzken SC, Schweingruber C, Reber S, Stettler J, Jutzi D, Mühlemann O, Colombo M   +41 more
core   +4 more sources

Targeting the CRYAB/β‐Catenin Axis with an MMP‐9‐Responsive Hydrogel Disrupts CTC Clusters to Suppress Progression of Hepatocellular Carcinoma after Radiofrequency Ablation

Advanced Science, EarlyView.
The graphical abstract illustrates that sublethal thermal stress after iRFA upregulates the chaperone CRYAB in residual HCC cells, which stabilizes β‐catenin and drives a dual pathological program, including EMT and N2‐TAN polarization, thereby leading to heterotypic CTC cluster formation. The MMP‐9‐responsive hydrogel (XB@Gel) delivers XAV‐939 and BMS‐
Hui Chen, Danni Yang, Songying Pi, Yuhan Liu, Hongbin Huang, Feile Ye, Yuhong Lin, Zhongzhen Su, Yongquan Huang   +8 more
wiley   +1 more source

SIRT5‐Mediated Desuccinylation of ACAA2 Protects Against Calcium Oxalate‐Induced Kidney Injury by Regulating Fatty Acid Oxidation to Suppress Mitochondrial Oxidative Injury and Ferroptosis

Advanced Science, EarlyView.
The SIRT5/ACAA2 axis maintains lipid metabolic homeostasis in RTECs by promoting ACAA2 desuccinylation and preserving its stability and enzymatic activity, thereby sustaining FAO and limiting PUFA and PUFA‐containing phospholipid accumulation. Under CaOx stress, SIRT5 downregulation impairs FAO, promotes oxidative stress and ferroptosis, and enhances ...
Qinhong Jiang, Caitao Dong, Yuchen Liu, Yuanquan Lou, Wenlong Lin, Sheng Li, Ziqi He   +6 more
wiley   +1 more source

The FUS(s) about splicing

, 2014
Fused in sarcoma (FUS), also called translocated in liposarcoma (TLS), is a ubiquitously expressed DNA/RNA binding protein belonging to the TET family and predominantly localized in the nucleus.
Ruepp, Marc-David
core