Results 31 to 40 of about 59,959 (160)

A Critical Time Window of Neocortex Modulation for Remote Fear Memory in Rats and Humans

Advanced Science, EarlyView.
This study identifies a delayed consolidation window around 18 h after fear learning in the mPFC essential for remote fear memory. VTA dopaminergic input during this window sustains remote memory in rats, while non‐invasive stimulation of homologous human mPFC at the corresponding time selectively weakens remote but not recent fear memory, revealing a ...
Lu Cao, Yu‐Xin Zhang, Xiao‐Xing Liu, Zi‐Hang Li, Tang‐Sheng Lu, Jia‐Hui Deng, Wen Zhang, Peng Li, Xiao Lin, Shu‐Fei Feng, Ting‐Ting Li, Shi‐Qiu Meng, Xiang‐Dong Tang, Tian‐Ye Jia, Trevor W. Robbins, Jie Shi, Ying Han, Yan‐Xue Xue, Lin Lu, Kai Yuan   +19 more
wiley   +1 more source

A Rigid–Foldable Kirigami‐Inspired Metamorphic Mechanism With Programmable Motion Modes and Self‐Locking

Advanced Science, EarlyView.
Geometric constraint reconfiguration enables a rigid–foldable kirigami‐inspired mechanism to switch between twisting, directional translation, and self‐locking states. By encoding multifunctionality directly into its architecture, the mechanism achieves multimodal motion and passive locking without reassembly, providing a compact platform for adaptive ...
Jianlin Wang, Zhongmin Song, Ketao Zhang
wiley   +1 more source

ALS mutant FUS disrupts nuclear localization and sequesters wild-type FUS within cytoplasmic stress granules [PDF]

, 2013
Mutations in the gene encoding Fused in Sarcoma (FUS) cause amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disorder. FUS is a predominantly nuclear DNA- and RNA-binding protein that is involved in RNA processing.
Miller, CC, Catherine Manser, Claire Troakes, Troakes, C, Claudia Kathe, Boris Rogelj, Urwin, Hazel, Mitchell, JC, Scotter, EL, Kathe, Claudia, Nishimura, AL, Dragunow, M, Rogelj, Boris, Rogelj, B, Emma L. Scotter, Manser, Catherine, Urwin, H, Hortobágyi, Tibor, Shaw, Christopher E., Mitchell, Jacqueline C., Tibor Hortobágyi, Vance, Caroline; id_orcid, Agnes L. Nishimura, Nishimura, Agnes L., Caroline Vance, Jacqueline C. Mitchell, Dragunow, Mike, Shaw, CE, Vance, C, Scotter, Emma L., Troakes, Claire; id_orcid, Kathe, C, Hortobágyi, T, Manser, C, Mike Dragunow, Christopher E. Shaw, Hazel Urwin, Christopher C. Miller, Miller, Christopher C.; id_orcid   +38 more
core   +1 more source

Synaptic accumulation of FUS triggers age-dependent misregulation of inhibitory synapses in ALS-FUS mice [PDF]

, 2020
FUS is a primarily nuclear RNA-binding protein with important roles in RNA processing and transport. FUS mutations disrupting its nuclear localization characterize a subset of amyotrophic lateral sclerosis (ALS-FUS) patients, through an unidentified ...
Pérez-Berlanga, Manuela, Sahadevan, Sonu, Hembach, Katharina M, Robinson, Mark D, De Rossi, Pierre, Weber, Julien, Tantardini, Elena, Dupuis, Luc, Hruska-Plochan, Marian, Polymenidou, Magdalini, Schwarz, Petra   +10 more
core   +1 more source

Mechanochemical Activation of a Bridged‐Exciplex Optical Force Probe

Advanced Science, EarlyView.
A bridged‐exciplex optical force probe is synthesized, switching from solvatochromic charge‐transfer emission in the latent state to intense locally excited emission upon activation. This dual photophysical response with additional changes in quantum yield and fluorescence lifetime enables precise environmental sensing and distinct optical readouts ...
Ronja Schumann, Andreas Bock, Felix Majer, Michael Baumann, Michael Olney‐Fraser, Lev Kazak, Fedor Jelezko, Alexander J. C. Kuehne, Robert Göstl   +8 more
wiley   +1 more source

Iron‐Tannic Acid Hydrogel Mediated Mild Photothermal Therapy Combined With Ferroptosis Enhances Anti‐Tumor Immunity in Colorectal Cancer

Advanced Science, EarlyView.
An injectable gelatin‐based tannic acid–iron hydrogel with mild photothermal therapy could not only induce immunogenic cell death, but also elicit ferroptosis of both tumor cells and tumor‐associated macrophages, resulting in DC maturation, T‐cell infiltration and down‐regulation of ferroptosis‐sensitive M2‐type TAMs levels.
Yuan Zhu, Xi Yu, Tao Wang, Wanyi Liu, Chang Lu, Jiani Zhong, Yujie He, Wei Li, Kunxi Zhang, Peihao Yin, Zeting Yuan   +10 more
wiley   +1 more source

Multiplexed Profiling of Individual Extracellular Vesicles Reveals Lung Cancer‐Associated Protein Signatures

Advanced Science, EarlyView.
Cygnus (Cyclic‐imaging gateway to nanovesicles underlying signature) integrates multiplexed single‐EV protein imaging with a practical analysis workflow to examine EV phenotypes at vesicle, subpopulation, and sample scales. ABSTRACT Lung cancer is frequently diagnosed after curative treatment windows have narrowed, creating a need for minimally ...
Mi Hyeon Cho, Yein Chung, Yoonjeong Choi, Baekdong Cha, Jayeon Song, Nuri Oh, Ala Jo, Thomas S. C. Ng, Hyunho Kim, Hyun‐Kyung Woo, Chang Hyun Kim, Cesar M. Castro, Miles A. Miller, Hakho Lee   +13 more
wiley   +1 more source

Mesenchymal Stromal Cell‐Based Cell–Drug Conjugates for the Treatment of Acute Liver Failure

Advanced Science, EarlyView.
Mesenchymal stromal cell (MSC)‐based cell‐drug conjugates are constructed by anchoring rosiglitazone‐loaded nanoparticles onto the MSC surface. Sustained rosiglitazone release enhances MSC proliferation and paracrine activity while promoting anti‐inflammatory macrophage polarization.
Tenghui Ye, Jiamin Wu, Zixin Wu, Xi Liu, Jiajia Luo, Leyi Yang, Peng Shi   +6 more
wiley   +1 more source

Number of differentially expressed genes by mutant FUS, FUS overexpression, and FUS knock-down.

, 2013
Number of differentially expressed genes by mutant FUS, FUS overexpression, and FUS knock-down.
John E. Landers (172264), Marka van Blitterswijk (119410), Ashley Lyn Leclerc (400572), Eric T. Wang (256097), Pamela J. Keagle (400570), Jan H. Veldink (119438), David E. Housman (254310), Brad A. Friedman (400569), Leonard H. van den Berg (119440), Patrick Lowe (400571)   +9 more
core   +1 more source

FUS Interacts with HSP60 to Promote Mitochondrial Damage. [PDF]

, 2015
FUS-proteinopathies, a group of heterogeneous disorders including ALS-FUS and FTLD-FUS, are characterized by the formation of inclusion bodies containing the nuclear protein FUS in the affected patients.
Haipeng Cheng, Marsel Mesulam (2207017), Jianghong Liu (392919), Jianwen Deng (2207002), Jianghong Liu, Sidan Du (2207014), Sidan Du, Kazuo Fushimi, Eileen H. Bigio (85389), Haipeng Cheng (2207011), Eileen H Bigio, Mengxue Yang (2207005), Xiaoping Chen (42085), Kazuo Fushimi (36798), Jianwen Deng, Shufeng Sun (2196031), Qi Xu, Li Zhu, Shufeng Sun, Qi Xu (134661), Mengxue Yang, Yang Li (7082), Marsel Mesulam, Li Zhu (67404), Yang Li, Jane Y. Wu (36803), Yanbo Chen (2207008), Xiaoping Chen, Jane Y Wu, Yanbo Chen, Mesulam Marsel, Yang Mengxue, Cheng Haipeng, Du Sidan, Wu Jane Y., Xu Qi, Chen Yanbo, Chen Xiaoping, Liu Jianghong, Fushimi Kazuo, Deng Jianwen, Sun Shufeng, Zhu Li, Li Yang, Bigio Eileen H.   +44 more
core   +1 more source