Results 21 to 30 of about 59,959 (160)

MOGAD Is the Most Common Cause of Isolated Optic Neuritis in Children

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives The study aimed to characterize the clinical features, etiologies, and outcomes of isolated, first‐time pediatric ON in the post‐MOG‐IgG era. Methods This was a single‐center retrospective cohort study at Texas Children's Hospital of patients diagnosed with first‐time ON between 2018–2024, with follow‐up data collected through 2025.
Chaitanya Aduru, Akansha Chandrasekar, Kyla Blasingame, Jonathan Rosen, Jesse M. Levine, Karla Salazar, Madhuri Chilakapati, Rod Foroozan, Victoria Hardwick, Jonathan M. Yarimi, Nikita Shukla, Timothy E. Lotze, Kristen S. Fisher, Alexander J. Sandweiss   +13 more
wiley   +1 more source

Efficacy of Fampridine on Refractory Optic Neuritis in Neuromyelitis Optica Spectrum Disorders

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Neuromyelitis optica spectrum disorders (NMOSD) usually occur with acute refractory optic neuritis (ON). However, there is a lack of efficacious treatments to improve recovery. Since fampridine has been found to improve the prognosis of multiple sclerosis (MS) and MS‐related ON, it is necessary to explore the efficacy of fampridine ...
Hongxuan Wang, Wanru Chen, Xiangpen Li, Hengjian Lu, Chenguang Li, Xiaoni Zhang, Lulu Bu, Xiaoyu Xu, Qingyu Shen, Ying Peng   +9 more
wiley   +1 more source

Beyond Presumptions: Toward Mechanistic Clarity in Metal‐Free Carbon Catalysts for Electrochemical H2O2 Production via Data Science

Advanced Materials, EarlyView.
Metal‐free carbon catalysts enable the sustainable synthesis of hydrogen peroxide via two‐electron oxygen reduction; however, active site complexity continues to hinder reliable interpretation. This review critiques correlation‐based approaches and highlights the importance of orthogonal experimental designs, standardized catalyst passports ...
Dayu Zhu, Hsi‐wen Wu, Xiao Wang, Jie Zhang   +3 more
wiley   +1 more source

Organic Materials of Tomorrow: Horizons of Artificial Intelligence

Advanced Materials, EarlyView.
This review examines machine learning techniques accelerating the discovery of organic semiconductors by linking molecular structure to properties. Key methods include graph neural networks, generative models, and active learning. Applications to organic photovoltaics demonstrate practical impact.
Harold Mena, J. Terence Blaskovits, Kun‐Han Lin, Denis Andrienko   +3 more
wiley   +1 more source

Charge‐Reversed Lipid Nanoparticles Enable Encapsulation of Pt2L4 Nanocages for In vivo Anti‐Cancer Treatment

Advanced Materials, EarlyView.
Charge‐reversed lipid nanoparticles (revLNPs) enable efficient encapsulation and delivery of cationic Pt2L4 nanocages. Encapsulation preserves potent anticancer activity while improving circulation, reducing vascular leakage, and promoting favorable biodistribution in vivo.
Renzo A. Knol, Bochuan Hu, Eduard O. Bobylev, Martina Farber, Petrus C. M. Laan, Thomas J. F. Kock, Bauke Fontein, Johanna Erbani, Oscar Escalona‐Rayo, Seline S. Roose, Tom Keijer, Gabriel Forn‐Cuní, B. Ewa Snaar‐Jagalska, Leila Akkari, Joost N. H. Reek, Alexander Kros, Dennis Aschmann   +16 more
wiley   +1 more source

Mechanoactive Biomaterials for Cell–Matrix Mechanotransduction

Advanced Materials, EarlyView.
The graphical abstract shows how individual triggers (force, light, or temperature) and combined optothermal or receptor‐targeted actuation induce material responses at the tissue, cellular, and receptor scales. Their spatial (global or focused) and temporal (continuous or cyclic) modulation determines the resulting mechanical output.
Yi‐Tung Lu, Alison E. John, Marc A. Fernández‐Yagüe   +2 more
wiley   +1 more source

Molecular analysis of the FET family fusion oncoprotein FUS-DDIT3 [PDF]

, 2012
Chromosomal translocations leading to formation of tumor type specific fusion oncogenes are frequently found in human cancers. The FET family genes (FUS, EWSR1 and TAF15) occur in translocations with genes encoding various transcription factors in ...
Thomsen, Christer
core   +1 more source

Synaptic FUS accumulation triggers early misregulation of synaptic RNAs in a mouse model of ALS [PDF]

, 2021
International audienceMutations disrupting the nuclear localization of the RNA-binding protein FUS characterize a subset of amyotrophic lateral sclerosis patients (ALS-FUS).
Pérez-Berlanga, Manuela, Hembach, Katharina, Sahadevan, Sonu, Megat, Salim, Weber, Julien, Tantardini, Elena, Dupuis, Luc, Hruska-Plochan, Marian, Polymenidou, Magdalini, Robinson, Mark, Schwarz, Petra, de Rossi, Pierre, Schwarz, P. (Petra), Tantardini, Elena; https://orcid.org/, Magdalini Polymenidou, Robinson, M. (Mark D), De Rossi, Pierre; https://orcid.org/, Sahadevan, S. (Sonu), Pérez-Berlanga, Manuela; https://orcid.org/, Hruska-Plochan, M. (Marian), Robinson, Mark D; https://orcid.org/, Julien Weber, Hembach, K. (Katharina M), Tantardini, E. (Elena), Marian Hruska-Plochan, Polymenidou, Magdalini; https://orcid.org/, Sonu Sahadevan, Schwarz, Petra; https://orcid.org/, Manuela Pérez-Berlanga, Dupuis, Luc; https://orcid.org/, Katharina M. Hembach, Pérez-Berlanga, M. (Manuela), Mark D. Robinson, Salim Megat, Polymenidou, M. (Magdalini), Petra Schwarz, Dupuis, L. (Luc), Hembach, Katharina M; https://orcid.org/, Hruska-Plochan, Marian; https://orcid.org/, De Rossi, P. (Pierre), Weber, J. (Julien), Elena Tantardini, Luc Dupuis, Pierre De Rossi, Megat, S. (Salim)   +44 more
core   +1 more source

Muscle Control of an Extra Robotic Digit

Advanced Robotics Research, EarlyView.
This study compares muscle‐ and movement‐based control for operating a supernumerary robotic thumb. While movement control performs better in the proposed tasks, muscle‐based (EMG) control promotes broader motor learning. The results highlight the promise and challenges of using biosignals for human augmentation, offering new insights into intuitive ...
Julien Russ, Lucy Dowdall, Francesco Cenciarelli, Kitty Goodridge, Mabel Ziman, Hristo Dimitrov, Danielle Clode, Tamar R. Makin   +7 more
wiley   +1 more source

Frameshift peptides alter the properties of truncated FUS proteins in ALS-FUS [PDF]

, 2020
Mutations in the FUS gene cause a subset of ALS cases (ALS-FUS). The majority of FUS mutations are missense mutations affecting the nuclear localisation signal (NLS) of FUS.
Rabesahala de Meritens, Camille, An, Haiyan, Shelkovnikova, Tatyana A, Buchman, Vladimir L   +3 more
core   +1 more source