Results 91 to 100 of about 1,389,546 (315)

Safety aspects of infliximab in inflammatory bowel disease patients - A retrospective cohort study in 100 patients of a German University Hospital [PDF]

, 2004
Background: Infliximab, a chimeric anti-tumour necrosis factor monoclonal antibody with potent anti-inflammatory effects, represents an effective treatment option in patients with severe inflammatory bowel disease (IBD).
Ali Y, Baker D, Burkhard Göke, Cohen RD, Hanauer S, Hommes DW, Jani AL, Julia Seiderer, Puchner TC, Sample C, Sandborn WJ, Thomas Ochsenkühn   +11 more
core   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Breast feeding practices and views among diabetic women: a retrospective cohort study [PDF]

, 2007
Objective: to explore the pattern and experiences of breast-feeding practices among diabetic women. Design: retrospective cohort study using maternal records and postal questionnaires in a Baby-Friendly hospital. Participants: diabetic mothers including
Dickinson, F. M., Kalk, J., Payne, K., Soltani, H.   +3 more
core   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Hepatobiliary laboratory abnormalities among patients with chronic or persistent immune thrombocytopenia (ITP)

Annals of Hepatology, 2011
Therapies for immune thrombocytopenia (ITP) may be associated with abnormal hepatobiliary laboratory (HBL) values, but the epidemiology of these abnormalities is unknown in the ITP population.
Cheryl Enger, Dimitri Bennett, Katie L Dawson, Manuel A. Aivado, Dickens Theodore, Andrew T. McAfee   +5 more
doaj   +1 more source

Bariatric surgery and its impact on cardiovascular disease and mortality : A systematic review and meta-analysis [PDF]

, 2014
Copyright © 2014 Elsevier Ireland Ltd.
Anderson, Simon G, Keavney, Bernard D, Khan, Muhammad A, Kwok, Chun Shing, Loke, Yoon K, Mamas, Mamas A, Myint, Phyo Kyaw, Pradhan, Ashish   +7 more
core   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Retrospective cohort study of the risk of impaired glucose tolerance among shift workers

Scandinavian Journal of Work, Environment & Health, 2012
OBJECTIVES: The aim of this study was to investigate the effect of shift working on the risk of developing impaired glucose tolerance (IGT). METHODS: This study comprised 6413 male employees (5608 daytime workers, 512 3-shift workers and 293 2-shift ...
Ichiro Oyama, Tomohide Kubo, Yoshihisa Fujino, Koji Kadowaki, Masamizu Kunimoto, Kiyoyumi Shirane, Hidetoshi Tabata, Ken Sabanai, Takehiro Nakamura, Shinya Matsuda   +9 more
doaj   +1 more source

Anthropometric indices of Gambian children after one or three annual rounds of mass drug administration with azithromycin for trachoma control. [PDF]

, 2014
BACKGROUND: Mass drug administration (MDA) with azithromycin, carried out for the control of blinding trachoma, has been linked to reduced mortality in children.
A Amza, A Amza, A Sommer, A Weisz, AE Roth, AJ Weisz, Ansumana Sillah, C Nokes, C Panter-Brick, CG Victora, CJ Whitty, CL Coles, CL Coles, D Stare, David C W Mabey, EJ Giamarellos-Bourboulis, EK Gough, EM Harding-Esch, EM Harding-Esch, Emma M Harding-Esch, EV Basilion, I Udan, JD Keenan, JH Humphrey, John Hart, KL Kotloff, KN Ryan, L Leonor Rodríguez, LS Stephenson, Martin J Holland, MG Rowland, MG Rowland, MP Eccles, P Aaby, PG Lunn, R Goto, RL Guerrant, Robin L Bailey, S Haug, Sarah E Burr, T Edwards, Tansy Edwards, TC Porco, WHO, WHO, WHO, WHO   +46 more
core   +2 more sources

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source