Results 151 to 160 of about 1,246,243 (313)

On “A Retrospective Cohort Study of Male Workers Exposed to PVA Fibers”

, 2000
Joris H. van Cleemput, Kenji Morinaga
openalex   +2 more sources

Retrospective cohort study examining incidence of HIV and hepatitis C infection among injecting drug users in Dublin [PDF]

, 2003
Bobby P. Smyth
openalex   +1 more source

Unraveling the Role of MDK‐SDC4 Interaction in Pancreatic Cancer‐Associated New‐Onset Diabetes by Single‐Cell Transcriptomic Analysis

Advanced Science, EarlyView.
Midkine (MDK) is a mediator of the interaction between pancreatic cancer and beta cells. MDK, which originated from pancreatic ductal adenocarcinoma cells, exerted deleterious effects on paraneoplastic beta cells by binding to the SDC4 receptor on the beta cell surface and subsequently downregulating the Ras signaling pathway, thereby impairing insulin
Zengyu Feng, Jianyao Lou, Chuanshuai Lin, Haocheng Yu, Yuheng Tu, Jiali Gong, Xiawei Li, Yulian Wu   +7 more
wiley   +1 more source

A RETROSPECTIVE COHORT STUDY OF WATER DISINFECTION BY-PRODUCTS AND ADVERSE HUMAN BIRTH OUTCOMES IN GREAT BRITAIN

, 2000
M. Toledano, P. Elliott, M. Niewenhuijsen, Heather Whitaker, Nicky Best, Samantha Cockings, Lars Järup, John Fawell   +7 more
openalex   +1 more source

Perinatal mortality in rural China: retrospective cohort study [PDF]

, 2003
Zhongwei Wu
openalex   +1 more source

Epigenetic Activation of CCDC183‐AS1 Promotes Osteoclastogenesis and Prostate Cancer Bone Metastasis Through the FUBP1/LIGHT Axis

Advanced Science, EarlyView.
CCDC183‐AS1 overexpression enhanced the ability of PCa cells to spread to the bone by inducing osteoclastogenesis. Mechanistically, CCDC183‐AS1 interacted with FUBP1 and enhanced its stability, which promoted the transcription of TNFSF14 (LIGHT). Copy number gain‐induced KDM5C epigenetically upregulated CCDC183‐AS1 expression by recruiting TET1 to the ...
Chuandong Lang, Xiangyu Mu, Kun Chen, Xinwen Wang, Yuluo Rong, Jia Wang, Zongcheng Yang, Chi Yin, Yuhu Dai, Jun Xiao, Wenzhi Zhang   +10 more
wiley   +1 more source

The LDH‐H3K18La‐Nur77 Axis Potentiates Immune Escape in Small Cell Lung Cancer

Advanced Science, EarlyView.
Lactate from SCLC tumors induces H3K18 lactylation in naïve CD8+ T cells, upregulating Nurr77 and enhancing tonic TCR signaling. This leads to T cell hyporesponsiveness to stimulation, impairing antitumor immunity and reducing immunotherapy efficacy.
Xiaoling Shang, Bo Cheng, Chenyue Zhang, Chenglong Zhao, Ruiqing Wang, Xun Zhang, Dizhi Jiang, Xinyu Zhang, Xinyue Ma, Hongyuan Mao, Zerun Li, Chenhan Huang, Tianzi Wang, Kaiyue Guo, Liwen Wang, Ning Tang, Haiyong Wang   +16 more
wiley   +1 more source

Clinical characteristics of behçet's disease in palestine, a retrospective cohort study. [PDF]

BMC Rheumatol
Daraghma A, Baidoun L, Nazzal S, Hattab M, Jalamneh B, Abusalameh M, Hanbali R, Abdoh Q.   +7 more
europepmc   +1 more source

Aspirin, ibuprofen, and mortality after myocardial infarction: retrospective cohort study [PDF]

, 2003
Jeptha P. Curtis, Yongfei Wang, Edward L. Portnay, Frederick A. Masoudi, Edward P. Havranek, Harlan M. Krumholz   +5 more
openalex   +1 more source

Targeting Intratumoral Copper Inhibits Tumor Progression via p62‐Mediated EZH2 Degradation and Potentiates Anti‐PD‐1 Immunotherapy in Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
The authors find that by targeting intratumoral copper, they can enhance p62‐mediated ubiquitination of EZH2 at the Ub‐K63 site by suppressing copper binding to SMURF2, an E3 ligase of EZH2, leading to its autophagic degradation. This mechanism suppressed OSCC progression and potentiated anti‐PD‐1 immunotherapy, highlighting a potential new therapeutic
Xiaohu Lin, Wanling Chen, Bo Li, Zhang Zhao, Zhonglin Yu, Xu‐Yun Zhao, Xuan Zhou, Zhien Feng, Chengzhong Lin, Wei Cao   +9 more
wiley   +1 more source