Results 61 to 70 of about 2,782,077 (346)

Postsurgical prescriptions for opioid naive patients and association with overdose and misuse: retrospective cohort study

British medical journal, 2018
Objective To quantify the effects of varying opioid prescribing patterns after surgery on dependence, overdose, or abuse in an opioid naive population. Design Retrospective cohort study.
G. Brat, D. Agniel, A. Beam, Brian K. Yorkgitis, Mark C. Bicket, Mark L. Homer, Kathe P. Fox, Daniel B Knecht, C. McMahill-Walraven, N. Palmer, I. Kohane   +10 more
semanticscholar   +1 more source

A retrospective cohort study of 12,306 pediatric COVID-19 patients in the United States

Scientific Reports, 2021
Children and adolescents account for ~ 13% of total COVID-19 cases in the United States. However, little is known about the nature of the illness in children.
V. Parcha, Katherine S. Booker, R. Kalra, S. Kuranz, L. Berra, G. Arora, P. Arora   +6 more
semanticscholar   +1 more source

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

Prediabetes is associated with a higher serum neurofilament light chain level in adolescents

Frontiers in Endocrinology, 2023
ObjectiveSerum neurofilament light chain (sNfL) level, which is a biomarker indicative of neuroaxonal damage and cognitive impairment, has been reported in several neurological diseases.
Zheng Chen, Lan-Ping Wu, Tuo-Chao Peng
doaj   +1 more source

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source

Cluster of COVID-19 in northern France: A retrospective closed cohort study

medRxiv, 2020
Background: The Oise department in France has been heavily affected by COVID-19 in early 2020. Methods: Between 30 March and 4 April 2020, we conducted a retrospective closed cohort study among pupils, their parents and siblings, as well as teachers and ...
A. Fontanet, L. Tondeur, Y. Madec, Rebecca Grant, C. Besombes, N. Jolly, S. Fernandes Pellerin, M. Ungeheuer, Isabelle Cailleau, Lucie Kuhmel, S. Temmam, C. Huon, Kuang-Yu Chen, B. Crescenzo, S. Munier, C. Demeret, L. Grzelak, I. Staropoli, T. Bruel, P. Gallian, S. Cauchemez, S. van der Werf, O. Schwartz, M. Eloit, B. Hoen   +24 more
semanticscholar   +1 more source

Evaluation of KRAS and NRAS mutations in metastatic colorectal cancer: an 8‐year study of 10 754 patients in Turkey

Molecular Oncology, EarlyView.
This nationwide study evaluated KRAS and NRAS mutations in 10 754 Turkish patients with metastatic colorectal cancer. The results revealed a mutation frequency of 51.1%, with 46.6% having KRAS mutations, 4.5% having NRAS mutations, and 48.5% being wild‐type for both.
Gozde Kavgaci, Izzet Akiva, Yavuz Hakan Ozon, Hakan Berkil, Huseyin Karadayi, Omer Dizdar, Suayib Yalcin   +6 more
wiley   +1 more source

Factors associated with deaths by tuberculosis in the state of Mato Grosso, 2011-2020: retrospective cohort study [PDF]

Epidemiologia e Serviços de Saúde
Objective: To investigate factors associated with tuberculosis deaths in Mato Grosso state, Brazil, from 2011 to 2020. Methods: Retrospective cohort study with data obtained from the Notifiable Health Conditions Information System and the Mortality ...
Vanessa da Silva Lopes, Rodrigo de Macedo Couto, Alexandre Peron da Luz, Pãmela Rodrigues de Souza Silva, Jaqueline Costa Lima   +4 more
doaj   +1 more source

Comprehensive omics‐based classification system in adult patients with B‐cell acute lymphoblastic leukemia

Molecular Oncology, EarlyView.
The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song, Ting Liu, Qishan Hao, Qiuyun Fang, Xiaoyuan Gong, Yan Li, Zheng Tian, Hui Wei, Min Wang, Jianxiang Wang, Tao Cheng, Yingchang Mi   +11 more
wiley   +1 more source

Periodontitis and Subsequent Risk of Cataract: Results From Real-World Practice

Frontiers in Medicine, 2022
BackgroundPeriodontitis can lead to systemic inflammation and oxidative stress, contributing to the development of various diseases. Periodontitis could also be associated with several ocular diseases.MethodsWe conducted a retrospective population-based ...
Li-Jen Yeh, Li-Jen Yeh, Te-Chun Shen, Te-Chun Shen, Kuo-Ting Sun, Cheng-Li Lin, Ning-Yi Hsia   +6 more
doaj   +1 more source