Results 281 to 290 of about 168,869 (309)
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Unraveling retrovirus integration
Cell, 1990Compared with prokaryotic mobile DNA elements, the study of recombination mechanisms and proteins involved in the integration of vertebrate retroviruses is in its infancy. Genetic and biochemical studies have provided critical insights into defining the role in integration of both the retrovirus-encoded DNA endonuclease and the cisacting long terminal ...
D P, Grandgenett, S R, Mumm
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Herpesvirus / Retrovirus Chimeric Vectors
Current Gene Therapy, 2004Over the years, the design of HSV-1 based vectors has developed from different types of replicative-defective and replication-conditioned recombinant viruses to plasmid based amplicon vectors. More recently hybrid or chimeric vectors have incorporated desired elements of different viruses to increase the efficacy of gene delivery in vitro and in vivo ...
EPSTEIN AL, MANSERVIGI, Roberto
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Retrovirus Envelope Glycoproteins
1990The envelope glycoprotein complex of replication competent retroviruses is comprised of two polypeptides, an external, glycosylated, hydrophilic polypeptide (SU) and a membrane-spanning protein (TM), that form a knob or knobbed spike on the surface of the virion.
E, Hunter, R, Swanstrom
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Retrovirus-Associated Myelopathies
Archives of Neurology, 1987Human T-lymphotropic virus type I (HTLV-I), the causative agent of adult T-cell leukemia and non-Hodgkin's lymphoma (ATLL)--or a cross-reacting retrovirus--has been associated with tropical spastic paraparesis in Martinique, Jamaica, Colombia, Trinidad and Tobago, the Seychelles, and probably also in Zaire.
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Human Gene Therapy, 1990
Retroviral vectors promote the efficient transfer of genes into a variety of cell types from many animal species. An important contribution to their utility was the development of retrovirus packaging cells, which allow the production of retroviral vectors in the absence of replication-competent virus.
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Retroviral vectors promote the efficient transfer of genes into a variety of cell types from many animal species. An important contribution to their utility was the development of retrovirus packaging cells, which allow the production of retroviral vectors in the absence of replication-competent virus.
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Retrovirus-Induced Acquired Immunodeficiencies
1985Publisher Summary This chapter discusses the Retrovirus (RV)-induced acquired immunodeficiency. It deals primarily with the former type of mechanisms, but emphasizes that distinguishing between tumors-unrelated and tumor-dependent immunodepressive events may be exceedingly difficult. RV can adversely affect the functioning of the immune system.
M, Bendinelli, D, Matteucci, H, Friedman
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