Results 111 to 120 of about 124,737 (275)

Cell Culture Substrate Variation Alters Extracellular Vesicle Biogenesis Without Affecting Non‐Coding Repeat RNA Profile

Small, EarlyView.
Cell culture biomechanical conditions influence extracellular vesicles (EVs) production in patient‐derived pancreatic adenocarcinoma (PDAC) cell lines. When grown in 3D conformation and in hydrogels with lower elasticity (0.5kPA), PDAC cells produce higher numbers of EVs, compared with cells grown in 2D on classic cell culture plastic.
Sara I. Veiga, Rebecca L. Porter, Berent Aldikacti, Uma K. Paithankar, Kate Calhoun, Eric Tai, Vishal Thapar, Jillian F. Wise, David T. Ting, Shannon L. Stott   +9 more
wiley   +1 more source

On the Selective Packaging of Genomic RNA by HIV-1

Viruses, 2016
Like other retroviruses, human immunodeficiency virus type 1 (HIV-1) selectively packages genomic RNA (gRNA) during virus assembly. However, in the absence of the gRNA, cellular messenger RNAs (mRNAs) are packaged.
Mauricio Comas-Garcia, Sean R. Davis, Alan Rein   +2 more
doaj   +1 more source

Comparison of the Prevalence of Bovine Leukemia Virus (BLV) in Holstein and Angus Cattle Breeds From Shandong Province, China

Microbiology and Immunology, EarlyView.
ABSTRACT Bovine leukemia virus (BLV) is widespread globally and causes economic losses in the cattle industry. Shandong Province plays a significant role in China's livestock industry, with an increasing importance in food of Holstein and Angus cattle. However, BLV prevalence in Holstein and Angus breeds in Shandong Province remains unclear.
Jingyuan Wang, Lin Dong, Guangjun Guo, Chunyang Yao, Changjiang Wang, Fengrong Tian, Feng Wei, Jishan Liu, Xuebo Wang, Ryosuke Matsuura, Sonoko Watanuki, Yasunobu Matsumoto, Jinliang Wang, Yoko Aida   +13 more
wiley   +1 more source

Infection of B Cell Follicle-Resident Cells by Friend Retrovirus Occurs during Acute Infection and Is Maintained during Viral Persistence

mBio, 2019
B cell follicles of the spleen and lymph nodes are immune privileged sites and serve as sanctuaries for infected CD4+ cells in HIV infection. It is assumed that CD8+ T cell responses promote the establishment of the reservoir, as B cell follicles do not ...
Sonja Windmann, Lucas Otto, Camilla Patrizia Hrycak, Anna Malyshkina, Nadine Bongard, Paul David, Matthias Gunzer, Ulf Dittmer, Wibke Bayer   +8 more
doaj   +1 more source

Increasing the scope and intensity of interventions to prevent HIV infection in infants: Best interests of women and children. [PDF]

, 2007
A
Chersich, Matthew, LUCHTERS, S.M.F., Temmerman, Marleen   +2 more
core   +1 more source

Upregulation of sphingomyelin and ABCA8 in response to TDP‐43 pathology in amyotrophic lateral sclerosis brain

Brain Pathology, EarlyView.
Increases in sphingomyelin in response to TDP‐43 pathology in the disease‐affected motor cortex of amyotrophic lateral sclerosis (ALS) brain. Abstract Amyotrophic lateral sclerosis (ALS) is a rapidly progressing neurodegenerative disease characterized by the degeneration of motor neurons and the presence of TAR DNA‐binding protein 43 (TDP‐43 ...
Finula I. Isik, Russell Pickford, Nicolas Dzamko, Kerry‐Anne Rye, Woojin Scott Kim   +4 more
wiley   +1 more source

Imaging Retroviral RNA Genome Heterodimers Using Bimolecular Fluorescence Complementation (BiFC)

Viruses
Retroviruses are single-stranded RNA viruses that package two copies of their positively stranded RNA genomes as a non-covalent dimer into newly formed virions.
Eunice C. Chen, Rebecca K. Maldonado, Leslie J. Parent   +2 more
doaj   +1 more source

Endogenous Retroviruses: With Us and against Us [PDF]

, 2017
Thomas J. Meyer, Jimi L. Rosenkrantz, Lucia Carbone, Shawn L. Chavez   +3 more
openalex   +1 more source

Roles of TIF1β in Leukemic Stem Cell Through SETDB1‐Dependent and Independent Mechanisms

Cancer Science, EarlyView.
In leukemic stem cell, BCR::ABL cooperates with TIF1β to open chromatin at oncogenes and close chromatin at differentiation regulators, driving leukemic reprogramming. In TIF1β‐deficient stem cell, the loss of TIF1β inverts this balance, showing closed chromatin at oncogenes and open chromatin at differentiation regulators.
Mariko Morii, Sho Kubota, Goro Sashida
wiley   +1 more source

SARS‐CoV‐2 nucleocapsid protein variants have differential RNA chaperone activity

The FEBS Journal, EarlyView.
The SARS‐CoV‐2 nucleocapsid (N) protein facilitates RNA annealing through its RBD–IDR2–CTD region, identifying it as a functional RNA chaperone. The Omicron BA.5 variant shows reduced chaperone activity compared to the Wuhan wild‐type protein. Although phosphorylation has no effect on wild‐type N, phosphomimetic modification of BA.5 N restores its RNA ...
Sabrina Babl, Julia M. Seidel, Fabian Kugler, Elisabeth Silberhorn, Anna Ludwig, Jonas Abel, Sophia Winklbauer, Niklas Schaub, Silvia Materna‐Reichelt, Kamran Honarnejad, Nataša Stojanović Gužvić, Gernot Längst   +11 more
wiley   +1 more source