Results 121 to 130 of about 120,627 (303)
Medicinal Research Reviews, EarlyView.ABSTRACT Autophagy is a highly conserved intracellular process involved in maintaining homeostasis and in the degradation of damaged organelles and external pathogens. Nature provides complex and varied reservoirs of scaffolds and chemical entities that may have a pivotal role in the search for new therapeutic leads.
Ilaria Cursaro +5 more
wiley +1 more source
Reticuloendotheliosis virus: detection of immunological relationship to mammalian type C retroviruses [PDF]
, 1979 Howard P. Charman +2 more
openalex +1 more source
Investigating Virus Clearance via pH Inactivation During Biomanufacturing [PDF]
, 2019 In the processing of biopharmaceuticals, viral clearance and viral safety are important for the development of monoclonal antibodies. Murine xenotropic leukemia virus (XMuLV) is one of the retroviruses, recommended by Food and Drug Administration (FDA ...
Xu, Wenbo
core +2 more sources
Update on Gene Therapy in the Treatment of Hereditary Hearing Loss
Sensory Neuroscience, EarlyView.Gene therapy is a promising therapeutic approach for genetic disorders, including three major gene therapy strategies: gene replacement, gene suppression, and gene editing. After transmitting genes to the inner ear through appropriate pathways, repair the cochlea in order to achieve the goal of treating hereditary hearing loss.
Weiwei He +7 more
wiley +1 more source
Genetic requirement for Ras in the transformation of fibroblasts and hematopoietic cells by the Bcr-Abl oncogene. [PDF]
, 1995 To determine the functional importance of Ras in transformation by Abl oncogenes, we used a genetic approach to measure the effect of impaired Ras activity on the ability of Bcr-Abl or v-Abl to transform cells.
McLaughlin, J, Sawyers, CL, Witte, ON
core
The discovery of endogenous retroviruses [PDF]
Retrovirology, 2006 When endogenous retroviruses (ERV) were discovered in the late 1960s, the Mendelian inheritance of retroviral genomes by their hosts was an entirely new concept. Indeed Howard M Temin's DNA provirus hypothesis enunciated in 1964 was not generally accepted, and reverse transcriptase was yet to be discovered.
openaire +5 more sources
Nature Inspired Delivery Vehicles for CRISPR‐Based Genome Editing
Small, EarlyView.The review highlights nature‐inspired nanocarriers for CRISPR delivery, emphasizing viral vectors, extracellular vesicles, liposomes, and lipid nanoparticles. It discusses their roles in improving specificity, minimizing immunogenicity, and overcoming barriers in genome editing. Recent advancements, challenges, and therapeutic applications are explored,
Elizabeth Maria Clarissa +4 more
wiley +1 more source
Multigene Family of Endogenous Retroviruses: Recombinant Origin of Diversity<xref ref-type="fn" rid="FN3">3</xref> [PDF]
, 1978 John H. Elder +3 more
openalex +1 more source
Veterinary Record Case Reports, EarlyView.Abstract Two cases of sporadic multicentric lymphomas with mediastinal masses in goats are documented. The first case involved a 3.5‐year‐old male goat. Ultrasound imaging revealed an enlarged right perirenal lymph node, which was confirmed as lymphoma through incisional biopsy and cytopathological analysis. Despite treatment, the goat succumbed to the
Angélica Consalter +6 more
wiley +1 more source
Type C Retroviruses as Vectors for Cloning Cellular Genes With Probable Transforming Function<xref ref-type="fn" rid="FN4">4</xref> [PDF]
, 1979 John Stephenson +3 more
openalex +1 more source