Results 141 to 150 of about 124,737 (275)

Cell and Gene Therapy in Equine Ocular Disease

open access: yesVeterinary Ophthalmology, Volume 29, Issue 2, March 2026.
ABSTRACT Equine ocular disease is common and often challenging to treat using traditional methods. This has led to the development of new therapies. Like human medicine, veterinary medicine is adopting cellular and gene therapy as innovative approaches. Equine ocular disease is a particularly promising area for these techniques.
Kimberly A. S. Young   +2 more
wiley   +1 more source

Analysis of the impact of TRIM5 polymorphism on retroviral replication [PDF]

open access: yes
This project aims to improve the SIV/rhesus macaques animal model for AIDS. TRIM5α is an antiviral molecule expressed in mammals including rhesus macaques.
Maplanka, Charlotte
core  

Integrated scFv identification and CAR T cell generation for AML targeting in vivo

open access: yesInternational Journal of Cancer, Volume 158, Issue 4, Page 994-1007, 15 February 2026.
What's new? Acute myeloid leukemia (AML) is a rapidly progressing blood cancer. Advancing chimeric antigen receptor (CAR) T cell therapies, particularly through rapid translation of single chain variable fragment (scFv) discovery into CAR constructs, may improve clinical outcomes, especially the development of patient individualized CAR T cells.
Yi Liu   +13 more
wiley   +1 more source

Classification of Retroviruses Based on Genomic Data Using RVGC

open access: diamond, 2021
Khalid Mahmood Aamir   +5 more
openalex   +1 more source

Targeting DESI2 as a Novel Therapeutic Strategy for JAK2‐Mutant Leukemias

open access: yesAdvanced Science, Volume 13, Issue 7, 3 February 2026.
Mass spectrometry‐based proteomics identify DESI2 as a novel component of the JAK2‐V617F complex, which associates with and stabilizes mutant JAK2 through deSUMOylation and deubiquitination, therefore promoting JAK2 mutant cell growth and MPN disease onset in vivo.
Husheng Mei   +32 more
wiley   +1 more source

Engineering Immortalized Bovine Granulosa Cells Using a Triple‐Gene Approach: Mutant CDK4, Cyclin D1, and TERT

open access: yesCell Biology International, Volume 50, Issue 2, February 2026.
ABSTRACT Advancing reproductive technologies in livestock is essential to improve both productivity and genetic potential of cattle. Despite this importance, application of reproductive biotechnologies in cattle breeding remains limited. Bovine granulosa cells (bGCs), which are key components of the ovarian follicle, are critical in female reproduction
Lanlan Bai   +12 more
wiley   +1 more source

Aerobic Exercise Promotes Hippocampal Neurogenesis and Ameliorates Cognitive Dysfunction Induced by Unilateral Labyrinthectomy

open access: yesCNS Neuroscience &Therapeutics, Volume 32, Issue 2, February 2026.
UL induced significant spatial and non‐spatial cognitive dysfunction and hippocampal neurogenesis inhibition, whereas aerobic exercise intervention effectively reversed these impairments. Transcriptomic profiling and pharmacological evidence identified MHC class I/II–related pathways (H2‐K1, H2‐Eb1, CD74) as key mediators of the restorative effects of ...
Zhanghong Zhou   +13 more
wiley   +1 more source

Evolution and Distribution of Class II-Related Endogenous Retroviruses

open access: green, 2005
Robert J. Gifford   +4 more
openalex   +1 more source

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