Results 41 to 50 of about 3,503,846 (312)
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Estimating the occurrence probability of Spring Thunderstorms using Markov chain, Case Study: Tabriz [PDF]
مخاطرات محیط طبیعی, 2018 Thunderstorms are one of the climatic phenomena that cause numerous damages in different parts of the world, due to the accompaniment with thunder, high winds, hail and heavy precipitation. In this study, the probability of thunderstorm days in Tabriz in
Mohammadreza Azizzadeh +3 more
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Response of Ecohydrological Variables to Meteorological Drought under Climate Change
Remote Sensing, 2022 Drought is the most widespread climatic extreme that has negative impacts on ecohydrology. Studies have shown that drought can cause certain degrees of disturbances to different ecohydrological variables, but the duration and severity thresholds of ...
Yuan Zhang +3 more
doaj +1 more source
Return Periods of Hydrological Events [PDF]
Hydrology Research, 1977 A relation between return periods of hydrological events in annual maxima and partial duration series respectively is shown to be exactly fulfilled when the events take place according to a Poisson process. Furthermore it is shown that the relation can be used as a good approximation when dealing with more regular processes than the Poissonian. Finally
openaire +1 more source
Computing return times or return periods with rare event algorithms [PDF]
Journal of Statistical Mechanics: Theory and Experiment, 2018 The average time between two occurrences of the same event, referred to as its return time (or return period), is a useful statistical concept for practical applications. For instance insurances or public agency may be interested by the return time of a 10m flood of the Seine river in Paris.
Lestang, Thibault +4 more
openaire +5 more sources
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Molecular Oncology, EarlyView.Translational cancer research and its implementation through competitively selected Comprehensive Cancer Centers across Europe should be the primary policy focus for addressing the increasing cancer burden in Europe and counteract the present main strategy to convert cancer to a chronic disease.
Manuel Heitor +2 more
wiley +1 more source
Hydrologic Drought Frequency Analysis in Karkhe Basin Based on Bivariate Statistical Analysis
علوم آب و خاک, 2018 In recent years, the joint distribution properties of drought including severity and duration have been widely evaluated using copula. Few studies, however, have worked on drought modeling based on stream flow, especially in semi-arid regions such as the
F. Farsadnia +3 more
doaj
Extreme Wave Analysis for the Dubai Coast
Hydrology, 2022 This paper aims to present the result of commonly used extreme wave analysis distribution methods applied to a long-term wave hindcast at a point in the Arabian Gulf near the coastline of Dubai, United Arab Emirates.
Khaled Elkersh +2 more
doaj +1 more source