Results 51 to 60 of about 3,490,561 (312)

Extreme Wave Analysis for the Dubai Coast

open access: yesHydrology, 2022
This paper aims to present the result of commonly used extreme wave analysis distribution methods applied to a long-term wave hindcast at a point in the Arabian Gulf near the coastline of Dubai, United Arab Emirates.
Khaled Elkersh   +2 more
doaj   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

open access: yesMolecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg   +43 more
wiley   +1 more source

Responses of Runoff and Its Extremes to Climate Change in the Upper Catchment of the Heihe River Basin, China

open access: yesAtmosphere, 2023
Understanding the impact of climate change on runoff and its extremes is of great significance for water resource assessment and adaptation strategies, especially in water-scarce regions.
Zhanling Li   +3 more
doaj   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

open access: yesMolecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris   +10 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Day/night variations of myeloid and lymphoid cell subsets in the murine inguinal lymph node

open access: yesFEBS Open Bio, EarlyView.
The circadian system is involved in the temporal regulation of the immune system. Our study reveals that two innate immune populations, NKT cells and neutrophils, predominate at the beginning of the day in healthy mice, highlighting how the time of day influences immune responses.
Paula M. Wagner   +6 more
wiley   +1 more source

Correlation Analysis of Influencing Factors and the Monthly Displacement Increment of a Hydrodynamic Landslide Using a Pseudo-Maximum-Likelihood-Estimation-Mixed-Copula Approach

open access: yesFrontiers in Earth Science, 2021
Heavy rainfall and changes in the water levels of reservoirs directly affect the degree of landslide disasters in major hydropower project reservoir areas. Correlation analyses of rainfall- and water-level fluctuations with landslide displacement changes
Rubin Wang   +6 more
doaj   +1 more source

Estimation of the Return Periods in Hydrology

open access: yesAdvances in Environmental and Engineering Research, 2022
A filtered Poisson process is proposed as a model for river flows. With the help of real-life data, the model parameters are estimated. Mathematical formulae are derived in order to estimate the various return periods of the river. An application to two rivers shows that the point estimates are very close to the corresponding values computed by ...
openaire   +2 more sources

Return to education in Malaysia [PDF]

open access: yes, 2009
The aim of this paper is to present a picture of return to education in Malaysia over the period from 1984 to 1997 based on earning equations model. The paper employed a set of data comprising micro-level data from the Household Income Survey (HIS) for ...
Haris, Asmaddy   +2 more
core   +2 more sources

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

open access: yesFEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan   +6 more
wiley   +1 more source

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