Results 191 to 200 of about 380,531 (310)

Tissue oxygenation dynamics during transition from seizure to spreading depolarization in rat brain

Epilepsia, EarlyView.
Abstract Objective Spreading depolarization (SD) is a phenomenon underlying various neurological conditions, including epilepsy. Researchers have suspected that local tissue oxygenation breakdown induces spontaneous SD. In this study, we investigated the relationship between spontaneous epileptic seizures and SD, with a focus on the role of local ...
Jiayang Liu, Bruce J. Gluckman
wiley   +1 more source

Canadian Stroke Best Practice Recommendations Rehabilitation, Recovery, and Community Participation Following Stroke, Part Three: Optimizing Activity and Community Participation Following Stroke , 7th Edition Update, 2025. [PDF]

Am J Phys Med Rehabil
Yao JK, Salbach NM, Lindsay MP, Nelson MLA, Shi J, O'Connell C, Barclay R, Bastasi D, Boulos MI, Boyce J, Claveau G, Flowers HL, Foley N, Gopaul U, Kim ES, Lo A, McDonald AM, McIntyre A, O'Connor C, Patterson KK, Shoniker T, Wein T, Wright J, Yeates B, Yiu J, Martin C, Lund R, Mehrabi S, Blacquiere D, Timpson D, Swartz RH, Smith EE, Eskes GA, Ganesh A, Longman RS, Blake T, Celarie S, Greer LA, Masse J, Patel R, Tennen G, Vyas M, Ritsma B, Tang A, Auger LP, Beaumont J, Bowes R, Chibane IS, Courtice SJ, Delgado R, Dunlop M, Ghavami K, Guolla T, Kean D, MacFayden S, Paterson P, Shumway E, Tee A, Tsang CYH, Turnbull S, White K, Mountain A, Canadian Stroke Best Practice Recommendations Advisory Committee, in collaboration with the Canadian Stroke Consortium, Canadian Neurological Sciences Federation, and CanStroke Recovery Trials Platform.   +65 more
europepmc   +1 more source

Targeted senotherapy improves electrographic and behavioral outcomes in a mouse model of temporal lobe epilepsy

Epilepsia, EarlyView.
Abstract Objective Current pharmacotherapy for temporal lobe epilepsy (TLE) is limited to symptomatic treatment and leaves approximately one third of patients with inadequate seizure control. Discovering disease‐modifying targets is an unmet clinical need. We have previously identified senescent cells (SCs) as one such target. Many drugs that eliminate
David J. McFall, Abbas I. Hussain, Michelle Cho, Patrick A. Forcelli   +3 more
wiley   +1 more source

Predicting Adverse Outcomes in Older Adults with 72-Hour Emergency Department Returns: A Retrospective Cohort Study Developing the Rec-FLASH Score. [PDF]

Inquiry
Chen CT, Meng YH, Yu HH, How CK, Tung YC.   +4 more
europepmc   +1 more source

A consensus roadmap for post‐traumatic epilepsy: Clinical biomarkers, research priorities, policy barriers, and pathways to interventional trials

Epilepsia, EarlyView.
Abstract Understanding the mechanisms underlying post‐traumatic epilepsy (PTE) following traumatic brain injury (TBI), and developing strategies to prevent or modify its progression, has been the focus of large collaborative efforts within the epilepsy and TBI research communities for over a decade.
Elisa R. Zanier, Ilaria Lisi, Elaine K. O'Loughlin, Federico Moro, Edilberto Amorim, David L. Brody, Daniel J. Correa, Dominique Duncan, Pavel Klein, Firas H. Kobeissy, Wolfgang Löscher, Edward J. Needham, Asla Pitkänen, Mary Jo Pugh, Jack Somers, Annamaria Vezzani, Amy K. Wagner, Laura S. Lubbers, International Conference on PTE Attendees, Denes Agoston, Edilberto Amorim, Sneha Anand, Hibah Awwad, Ginevra Bayon, Naima Belhachemi, Akash Bera, Costanza Bertani, Guido Bertolini, David L. Brody, Serena Brusatori, Francesca Buffelli, Aurora Chiapperini, Mara Chioccola, Severn Churn, Daniel J. Correa, Ramon Diaz‐Arrastia, Chris Dulla, Dominique Duncan, Chiara Ferlito, Aristea Galanopoulou, Angela Galic, Heidi Matos Galicia, Bin Gu, William Haskins, Victoria Johnson, Nigel Jones, Lowie Joseph, Pavel Klein, Firas Kobaissy, Ilaria Lisi, David Loane, Luther Loose, Laura S. Lubbers, Wolfgang Löscher, Edoardo Mazzone, Melissa Miller, Federico Moro, Edward J. Needham, Irma Wati Ngadimon, Terence O’Brien, Elaine K. O’Loughlin, Asla Pitkanen, Mary Jo Pugh, Teresa Giovanna Ravizza, Giuseppe Remuzzi, Massimo Rizzi, Rossella Di Sapia, Tawfeeq Shekh‐Ahmad, Doug Smith, Jack Somers, Kevin Staley, Francesca Tribuzio, Alexandra Ulyanova, Gloria Vegliante, Annamaria Vezzani, Joost Wagenaar, Amy K. Wagner, Kevin W. Wang, Justin Weppner, Peter J. West, Karen Wilcox, John Wolf, Elisa R. Zanier   +82 more
wiley   +1 more source

Outdoor bicycle training following stroke: protocol development, feasibility testing and application guidelines. [PDF]

Front Rehabil Sci
Villeneuve M, Piché J, Busch A, Lamontagne A.   +3 more
europepmc   +1 more source

Cardiac remodeling and arrhythmia in a mouse model of Depdc5 haploinsufficiency

Epilepsia, EarlyView.
Abstract Objective Some ion channel genes linked to developmental and epileptic encephalopathy (DEE) are also linked to cardiac arrhythmia, leading to the hypothesis that predisposition to cardiac arrhythmias may contribute to the complex disease presentation of DEE and possibly to the mechanism of sudden unexpected death in epilepsy.
Roberto Ramos‐Mondragon, Shuyun Wang, Qinghua Liu, Chunling Chen, Alexander M. Greiner, Abigail M. Marx, Maya Shih, Jack M. Parent, Barry London, Lori L. Isom   +9 more
wiley   +1 more source

Long-Term Secondary Preventive Medication Persistence and Adherence in Young Ischemic Stroke Survivors: A Prospective Single-Center Cohort Study. [PDF]

Brain Behav
Wang Q, Tang M, Gao H, Sha Y, Yao M, Zhu Y, Peng B, Zhou L, Ni J.   +8 more
europepmc   +1 more source

Febrile status epilepticus and epileptogenesis: The FEBSTAT study

Epilepsia Open, EarlyView.
Abstract The multicenter FEBSTAT study (Consequences of Prolonged Febrile Seizures in Childhood: https://grantome.com/grant/NIH/R37‐NS043209‐12; PI S. Shinnar) examined the outcome of febrile status epilepticus (FSE) in over 200 prospectively enrolled infants, with many followed for 10 years after FSE.
Darrell V. Lewis, Douglas R. Nordli Jr., Douglas R. Nordli III, Shlomo Shinnar, Stephen Chan, Jacqueline A. Bello, L. Matthew Frank, James Voyvodic, William Gallentine, Syndi Seinfeld, Yoshimi Sogawa, Erica Weiss, David Masur, Yuan Xu, Solomon L. Moshé   +14 more
wiley   +1 more source

Incidence and outcomes of childhood status epilepticus in Kano, northern Nigeria

Epilepsia Open, EarlyView.
Abstract Objective Convulsive status epilepticus (CSE) is a major neurological emergency in childhood, but population‐based data from low‐ and middle‐income countries remain limited. We estimated the incidence, mortality, neurological outcomes, and predictors of adverse outcomes among children with CSE in Kano, northern Nigeria.
Umar A. Sabo, Halima Kabir, Aminu T. Abdullahi, Halima Adamu, Auwal S. Salihu, Abba M. Abdullahi, Aminu Wada, Zubairu Iliyasu, Jamilu Zakari, Safiya Gambo, Binta W. Jibir, Muktar H. Aliyu, Usman J. Wudil, Donna J. Ingles, Heather L. Prigmore, Bryan E. Shepherd, Angela R. Paolucci, Edwin Trevathan   +17 more
wiley   +1 more source