Results 51 to 60 of about 697,668 (218)

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

open access: yesFEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen   +9 more
wiley   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

open access: yesFEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

Research progress on readiness for return⁃to⁃work in patients with hand injuries

open access: yesHuli yanjiu
This article reviewed the concept and theoretical basis of readiness for return⁃to⁃work,as well as the status quo,influencing factors,and intervention measures related to the readiness for return⁃to⁃work in patients with hand injuries.The aim is to ...
ZHANG Xiaoyi, XU Pengzhu
doaj  

Resilience and workability among breast cancer survivors

open access: yesINFAD, 2019
Breast cancer is the most common neoplasia in women worldwide. Medical advances in prognosis and treatments have improved survival rates, however, many women report physical and psychological problems derived from the impact and the administered ...
Rocío Gómez- Molinero   +3 more
doaj   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

open access: yesFEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee   +6 more
wiley   +1 more source

How should methods for return to work be evaluated?

open access: yesScandinavian Journal of Work, Environment & Health, 2012
Measures to decrease early retirement are underway in many countries to increase the working population and lower costs. Sick leave is the normal pathway to early retirement and methods to enable persons on sick leave to return to work (RTW) earlier and ...
Bengt Järvholm
doaj   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

open access: yesFEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho   +4 more
wiley   +1 more source

Sick leave and a «Return-to-Work» programme – a prospective clinical study on patients with persistent low back pain

open access: yesFysioterapeuten, 2016
Objective: Explore 1-year course of sickleave and clinical outcome in patients with persistent low back pain (LBP) referred to «Raskere tilbake»*, and assess whether psychological factors predicted sickleave at 12 months follow-up.
Margreth Grotle   +2 more
doaj  

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