Results 11 to 20 of about 2,947,895 (397)

The serotonin reuptake inhibitor Fluoxetine inhibits SARS-CoV-2 [PDF]

bioRxiv, 2020
To circumvent time-consuming clinical trials, testing whether existing drugs are effective inhibitors of SARS-CoV-2, has led to the discovery of Remdesivir.
Melissa Zimniak, Luisa Kirschner, Helen Hilpert, Jürgen Seibel, Jochen Bodem   +4 more
openalex   +2 more sources

Mortality Risk Among Patients With COVID-19 Prescribed Selective Serotonin Reuptake Inhibitor Antidepressants

JAMA Network Open, 2021
Key Points Question Are selective serotonin reuptake inhibitors (SSRIs), specifically fluoxetine hydrochloride, associated with a lower mortality risk among patients with COVID-19?
T. Oskotsky, I. Marić, A. Tang, B. Oskotsky, R. Wong, N. Aghaeepour, M. Sirota, D. Stevenson   +7 more
semanticscholar   +1 more source

Right and Left-Sided Carcinoid Heart Disease in the Setting of Selective Serotonin Reuptake Inhibitor Use

JACC: Case Reports, 2020
Carcinoid heart disease is a complication of carcinoid syndrome. The role of selective serotonin reuptake inhibitors in carcinoid heart disease is unclear. We present a case of refractory heart failure due to right- and left-sided carcinoid heart disease
Jennifer Bell, MD, Maad Alhudairy, MD, Vera Kazakova, MD, Michael Johnstone, MD, Lana Tsao, MD   +4 more
doaj   +1 more source

Selective serotonin reuptake inhibitors in the treatment of generalized anxiety disorder [PDF]

, 2002
Selective serotonin reuptake inhibitors have proven efficacy in the treatment of panic disorder, obsessive–compulsive disorder, post-traumatic stress disorder and social anxiety disorder.
Allgulander C, Andrew Mayers, Ansseau M, Aufdembrinke B. Abercarnil,, Ballenger JC, Barlow DH, Beekman AT, Carter RM, Chamey DS, Christel Buis, Connor KM, David Baldwin, Davidson JR, Durham RC, Durham RC, ECNP Consensus meeting, March, Fairbanks JM, Fawcett J, Feighner JP, Field MJ, Fontaine R, Gammans RE, Gelenberg AJ, Goa KL, Goldberg HL, Gould RA, Gould RA, Hedges DW, Hurst M, Keller MB, Pollack MET, Power KG, Rickels K, Rocca P, Rocca P, Sevy S, Sitsen JMA, Sramek JJ, Stahl S, Wardle J, Weizman R, Wittchen HU   +41 more
core   +1 more source

Preclinical discovery of duloxetine for the treatment of depression [PDF]

, 2012
Introduction: Affective disorders, including major depressive disorder (MDD), are among the most severely disabling mental disorders, and in many cases areIntroduction: Affective disorders, including major depressive disorder (MDD), are among the most ...
Berrocoso Domínguez, Esther María, Elorza, Julián, Micó Segura, Juan Antonio, Perez-Caballero, Laura, Torres-Sanchez, Sonia   +4 more
core   +2 more sources

Psychotropic Drugs for the Management of Chronic Pain and Itch

Pharmaceuticals, 2019
Clinical observations have shown that patients with chronic neuropathic pain or itch exhibit symptoms of increased anxiety, depression and cognitive impairment. Such patients need corrective therapy with antidepressants, antipsychotics or anticonvulsants.
Daria A. Belinskaia, Mariia A. Belinskaia, Oleg I. Barygin, Nina P. Vanchakova, Natalia N. Shestakova   +4 more
doaj   +1 more source

Fluoxetine: a case history of its discovery and preclinical development [PDF]

, 2014
Introduction: Depression is a multifactorial mood disorder with a high prevalence worldwide. Until now, treatments for depression have focused on the inhibition of monoaminergic reuptake sites, which augment the bioavailability of monoamines in the CNS ...
Bel N, Bergstrom RF, Bravo L, Bremner JD, Burrows GD, Chouinard G, Datla KP, Esther Berrocoso, Juan Antonio Mico, Kreiss DS, Laura Perez-Caballero, Lemberger L, Li Q, Lidia Bravo, Maj J, Nibuya M, Owens MJ, Rutter JJ, Sonia Torres-Sanchez, Stevens JC, Wong DT   +20 more
core   +2 more sources

Selective serotonin reuptake inhibitors pathway [PDF]

Pharmacogenetics and Genomics, 2009
Serotonin (5-hydroxytryptamine, 5-HT) is a neurotransmitter that influences multiple processes, including autonomic function, motor activity, hormone secretion, cognition, and complex processes associated with affection, emotion, and reward [1]. In the terminal axon of the serotonergic neuron, free tryptophan (TRP) is converted to 5-HT [2].
Katrin, Sangkuhl, Teri E, Klein, Russ B, Altman   +2 more
openaire   +2 more sources

Mirtazapine decreases stimulatory effects of reboxetine on cortisol, adrenocorticotropin and prolactin secretion in healthy male subjects [PDF]

, 2004
Reboxetine is a selective noradrenaline reuptake inhibitor, whereas mirtazapine acts as an antagonist at noradrenergic alpha(2), serotonin (5-HT2), 5-HT3 and histamine H-1 receptors.
Baghai, Thomas C., Laakmann, G., Schule, C.   +2 more
core   +1 more source

Use of selective-serotonin reuptake inhibitors and platelet aggregation inhibitors among individuals with co-occurring atherosclerotic cardiovascular disease and depression or anxiety

SAGE Open Medicine, 2016
Objective: Medications commonly used to treat heart disease, anxiety, and depression can interact resulting in an increased risk of bleeding, warranting a cautious approach in medical decision making.
J Douglas Thornton, Parul Agarwal, Usha Sambamoorthi   +2 more
doaj   +1 more source