Results 1 to 10 of about 38,009 (171)

Fluoxetine disrupts cholesterol metabolism in endothelial cells via SREBP2 activation [PDF]

Translational Psychiatry
Fluoxetine is a selective serotonin reuptake inhibitor (SSRI) commonly prescribed for the treatment of depressive disorders. Recent clinical reports and studies in animal models have suggested that fluoxetine increases the risk of cardiovascular diseases,
Fabiana Oliveira, Christina Papa, Tobias Hagemann, Ruby Schipper, Florian Geier, Tino Röxe, Faiqa Zulfqar, Christoph Prönnecke, Lisa Schmidt, Hryhoriy Stryhanyuk, Anne Hoffmann, Anastasia Kyselova, Christina Karantanou, Yuli Buckley, Muhammad Asad Farhan, Jesús Rafael Rodríguez-Aguilera, Saira Ambreen, He Yao, Amna Arif, Hugo N. G. Martin, Thomas Ebert, Nora Klöting, Matthias Blüher, Khurrum Shahzad, Jes-Niels Boeckel, Carolina E. Hagberg, Rima Chakaroun, Sofia-Iris Bibli, Bilal N. Sheikh   +28 more
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Fluoxetine minimally affects hearing loss but induces gene expression changes in the cochlear nuclei after noise exposure. [PDF]

PLoS ONE
PurposeThis study investigated the effects of fluoxetine on noise-induced injuries to the cochlea and auditory nerve, with a focus on its impact on perineuronal nets (PNNs) and gene expression changes in the ventral cochlear nuclei (VCN).MethodsSprague ...
Hyun-Ju An, Sujin Choi, Soonchul Lee, Hyunjeong Yeo, So Young Kim   +4 more
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Fluoxetine Potentiates Phagocytosis and Autophagy in Microglia

Frontiers in Pharmacology, 2021
Fluoxetine is a classic antidepressant drug, and its immunomodulatory effects have recently been reported in many disease models. In addition, it has strong antineuroinflammatory effects in stroke and neurodegenerative animal models.
Sung Hee Park, Young-Sun Lee, Young-Sun Lee, Hyun-Jeong Yang, Gyun Jee Song, Gyun Jee Song   +5 more
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Assessing the Mechanism of Fluoxetine-Mediated CYP2D6 Inhibition

Pharmaceutics, 2021
Fluoxetine is still one of the most widely used antidepressants in the world. The drug is extensively metabolized by several cytochrome P450 (CYP450) enzymes and subjected to a myriad of CYP450-mediated drug interactions.
Malavika Deodhar, Sweilem B. Al Rihani, Lucy Darakjian, Jacques Turgeon, Veronique Michaud   +4 more
doaj   +1 more source

Fluoxetine exerts age-dependent effects on behavior and amygdala neuroplasticity in the rat. [PDF]

PLoS ONE, 2011
The selective serotonin reuptake inhibitor (SSRI) Prozac® (fluoxetine) is the only registered antidepressant to treat depression in children and adolescents.
Judith R Homberg, Jocelien D A Olivier, Tom Blom, Tim Arentsen, Chantal van Brunschot, Pieter Schipper, Gerdien Korte-Bouws, Gilles van Luijtelaar, Liesbeth Reneman   +8 more
doaj   +1 more source

Analysis of Adherence to Fluoxetine Treatment through its Plasma Concentration

Brazilian Journal of Pharmaceutical Sciences, 2023
Depression plays an important role in non-adherence to medical recommendations. Fluoxetine is a first line of depression treatment. This study aimed to evaluate adherence to drug therapy in fluoxetine users by different methods. A cross-section study was
Juliana Raquel Raasch, Tainara Gomes Vargas, Andressa Schmidt dos Santos, Roberta Ziles Hahn, Anne Caroline Cezimbra da Silva, Marina Venzon Antunes, Rafael Linden, Andresa Heemann Betti, Magda Susana Perassolo   +8 more
doaj   +1 more source

Antidepressants Fluoxetine Mediates Endoplasmic Reticulum Stress and Autophagy of Non–Small Cell Lung Cancer Cells Through the ATF4-AKT-mTOR Signaling Pathway

Frontiers in Pharmacology, 2022
Fluoxetine, one of the latest clinical antidepressants, is reported to have the anti-proliferative effect on cancer cells via immune-related pathways. However, the mechanism is still not known.
Shali Shao, Xibing Zhuang, Lin Zhang, Tiankui Qiao   +3 more
doaj   +1 more source

Fluoxetine improves bone microarchitecture and mechanical properties in rodents undergoing chronic mild stress – an animal model of depression

Translational Psychiatry, 2022
Depression is one of the most prevalent mental disorders associated with reductions in bone mineral density and increased fracture risk. Fluoxetine is a highly prescribed selective serotonin reuptake inhibitor (SSRI) in the treatment of depression and is
Raymond W. Lam, Hee-Kit Wong, Ramruttun A. Kumarsing, Anna N. Chua, Roger C. Ho, Roger S. McIntyre, Cyrus S. Ho   +6 more
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Factors associated with fluoxetine and norfluoxetine plasma concentrations and clinical response in Mexican patients with mental disorders

Pharmacology Research & Perspectives, 2021
Over the last few years, fluoxetine has been one of the most prescribed medications for the treatment of diverse psychiatric conditions in Mexico.
Julia Sagahón‐Azúa, Susanna Edith Medellín‐Garibay, Cinthya Eloisa Chávez‐Castillo, César Guillermo González‐Salinas, Rosa del Carmen Milán‐Segovia, Silvia Romano‐Moreno   +5 more
doaj   +1 more source

HISTOLOGICAL PROTECTIVE EFFECT OF WHEAT GERM OIL VERSUS ZINC ON FLUOXETINE –DAMAGED TESTES IN ALBINO RATS [PDF]

Ain Shams Medical Journal, 2023
Background: Fluoxetine is anti-depressive drug which induces oxidative stress in different organs, Wheat germ oil and zinc have anti-inflammatory and antioxidant effects.
heba Fawzy, Faten Mahmoud
doaj   +3 more sources