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Selective Serotonin Reuptake Inhibitors
2018The first antidepressants were created by chance but brought the idea that central serotonin agonism produced an antidepressant effect. SSRIs were the first class of psychotropic medications to be rationally designed, meaning that researchers intended to utilize a specific mechanism of action while avoiding adverse effects.
Dee, Lochmann, Tara, Richardson
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Bivalent biogenic amine reuptake inhibitors
Bioorganic & Medicinal Chemistry Letters, 2003A series of aryltropane-based bivalent ligands was prepared and investigated for binding potency and for their ability to inhibit reuptake of human dopamine, serotonin and norepinephrine transporters. The bivalent ligand 4, comprised of linking an aryltropane by an octamethylene spacer showed high efficacy for the human dopamine transporter and had a ...
Keith, Fandrick +4 more
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Duloxetine: A Dual Reuptake Inhibitor
Annals of Pharmacotherapy, 2004OBJECTIVE To review the pharmacology, pharmacokinetics, clinical efficacy, and safety profile of duloxetine for the treatment of major depressive disorder (MDD). DATA SOURCES Searches using MEDLINE and PsycINFO were conducted (1966 to November 2003). STUDY SELECTION AND DATA EXTRACTION All duloxetine MDD information gathered was considered.
Sara E, Dugan, Matthew A, Fuller
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Selective Serotonin Reuptake Inhibitors
2016Selective serotonergic reuptake inhibitors (SSRIs) are a class of medications used frequently to address issues related to stroke and post-stroke recovery. Health care providers who care for stroke patients will need to familiarize themselves with their applications in stroke treatment.
Ali Saad +2 more
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Selective serotonin reuptake inhibitors
Nurse Prescribing, 2010Selective serotonin reuptake inhibitors (SSRIs) are used widely for the treatment of depression and anxiety disorders, and different SSRIs have different licence indications. They prevent the reuptake of serotonin in the synapse between nerve cells; they should be used with caution in children and adolescents owing to the possible side-effect of an ...
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Serotonin and Norepinephrine Reuptake Inhibitors
2018This chapter covers antidepressants that fall into the class of serotonin (5-HT) and norepinephrine (NE) reuptake inhibitors. That is, they bind to the 5-HT and NE transporters with varying levels of potency and binding affinity ratios. Unlike the selective serotonin (5-HT) reuptake inhibitors (SSRIs), most of these antidepressants have an ascending ...
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Selective Serotonin Reuptake Inhibitors
2011Selective serotonin reuptake inhibitors (SSRIs) are one of the newer classes of antidepressants. Since their introduction in the United States, they have been greatly used and accepted in the psychiatric field (1). SSRIs presently available in the United States include fluoxetine, paroxetine, sertraline, fluvoxamine, and citalopram.
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Postpartum Hemorrhage and Use of Serotonin Reuptake Inhibitor Antidepressants in Pregnancy
Obstetrics and Gynecology, 2016G. Hanley +4 more
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