Results 51 to 60 of about 89,927 (348)

De‐Saturation of Single‐Atom Copper Catalysts for Accelerating Propargylic Substitution Reactions

Advanced Materials, EarlyView.
De‐saturation of copper‐based single‐atom catalysts (De‐sat SACs) are realized by a KOH‐mediated Joule thermal shock strategy. Benefiting from the under‐saturation coordination environment of single‐atom Cu center, De‐sat Cu SACs exhibit remarkable catalytic activity in propargylic substitution reactions, tolerating a broad range of nucleophiles (N–, C–
Qilong Cai, Yang Meng, Chao Wu, Wenjia Qu, Qiang Wang, Tan Li, Chengyi Liu, Jinxing Chen, Huihui Lin, Qian He, Yafei Zhao, Shibo Xi, Jiong Lu   +12 more
wiley   +1 more source

Thrombocytopenia due to escitalopram use – A rare case report at the emergency department

Iraqi Journal of Hematology, 2021
Selective serotonin reuptake inhibitors are commonly used in the treatment of many psychiatric diseases today. Their common side effects consist of gastrointestinal side effects, sexual dysfunction, headache, insomnia, and sedation, whereas hematological
Cihan Bedel, Mustafa Korkut
doaj   +1 more source

The reported use and effectiveness of Hypericum (St John’s wort) on affective symptoms in a depression self-help group [PDF]

, 2002
A recent meta-analysis suggested that Hypericum perforatum (St John’s wort) is an effective treatment for mild to moderate depression and may have a superior side-effect profile to some antidepressant drugs.
Baldwin, D.S., Dyson, R., Jenkins, G., Mayers, A.G., Tiernan, A.   +4 more
core   +1 more source

Pigment Epithelium‐Derived Factor Deficiency Impairs Hippocampal Glutamate Homeostasis and Cognitive Function by Downregulating Astrocytic GLT‐1

Advanced Science, EarlyView.
The chronic glutamate‐induced excitotoxicity hypothesis has profoundly informed the therapeutic strategies employed in Alzheimer’s disease (AD). This study shows pigment epithelium‐derived factor (PEDF) regulates astrocytic glutamate transporter‐1 (GLT‐1)‐mediated glutamate homeostasis and cognition. Reduced PEDF correlates with lower Mini‐Mental State
Jin‐Hui Shi, Qi‐Long Tang, Jin‐Hong Wang, Yan‐Lan Long, Sai‐Feng Zhao, Zhen Zhao, Wan‐Ting Xie, Zi‐Ming Li, Hao‐Ming Lu, Tian‐Xiao Gao, Zhen‐Zhen Fang, Ti Zhou, Bo‐Xing Li, Xia Yang, Guo‐Quan Gao, Wei‐Wei Qi   +15 more
wiley   +1 more source

Monoamine Depletion by Reuptake Inhibitors [Expression of Concern]

Drug, Healthcare and Patient Safety, 2020
Hinz M, Stein A, Uncini T. Drug Healthc Patient Saf. 2011;3:69–77. The Editor-in-Chief and Publisher of Drug, Healthcare and Patient Safety wish to issue an Expression of Concern for the published article.
Hinz M, Stein A, Uncini T
doaj  

Time‐Dependent Therapeutic Effect of S‐Ketamine on PTSD Mediated by VTA‐OFC Dopaminergic Neurocircuit

Advanced Science, EarlyView.
This study reveals that early rather than late administration of S‐ketamine can ameliorate PTSD symptoms. This phenomenon is attributed to reversing the progressive inhibition of VTADA neurons and the function of VTADA‐OFC circuit following stress. Targeted stimulation of the OFC by TI‐NIBS to enhance DA release effectively extends the therapeutic time
Ye Wang, Lei Liu, Jinghao Wang, Jiannan Li, Huiming Li, Rui Wang, Hui Wang, Min Wang, Quanying Liu, Zhongmin Fan, Yunyun Zhang, Xinxin Zhang, Dan Wang, Sa Wang, Rou Xue, Jindong Mao, Min Cai, Pengfei Wei, Hailong Dong, Yumei Wu, Guangchao Zhao   +20 more
wiley   +1 more source

Aluminum Exposure Impairs Electrochemically Measured Vesicular Storage and Exocytosis via Iron Homeostasis Dysregulation

Angewandte Chemie, EarlyView.
Al3+ competes with Fe3+ for transferrin (Tf) binding and enters cells via transferrin receptor (TfR)‐mediated endocytosis, disrupting cellular iron homeostasis. Intracellular vesicle impact electrochemical cytometry (IVIEC) and single‐cell amperometry (SCA), which record the oxidation of dopamine, reveal increased neurotransmitter storage and ...
Shi‐Hua Chen, Chaoyi Gu, Xing‐Jiu Huang, Andrew G. Ewing   +3 more
wiley   +2 more sources

Monoamine Depletion by Reuptake Inhibitors [Retraction]

Drug, Healthcare and Patient Safety, 2020
Hinz M, Stein A, Uncini T. Drug Healthc Patient Saf. 2011;3:69–77. The Editor-in-chief and Publisher of Drug, Healthcare and Patient Safety wish to retract the published article.
Hinz M, Stein A, Uncini T
doaj  

Polypharmacy Leading to Priapism in HIV Patient with Schizoaffective Disorder: A CYP450 Cascade

Case Reports in Psychiatry, 2019
With increasing trend of polypharmacy, there are higher chances of drug-drug interactions leading to adverse effects, especially in psychiatric patients with co-morbid chronic medical problems. This case demonstrates a schizoaffective 30-year-old male on
Vinod Sharma, Aditi Sharma
doaj   +1 more source

Evaluation of machine-learning methods for ligand-based virtual screening [PDF]

, 2007
Machine-learning methods can be used for virtual screening by analysing the structural characteristics of molecules of known (in)activity, and we here discuss the use of kernel discrimination and naive Bayesian classifier (NBC) methods for this purpose ...
A Bender, A Bender, A Bender, A Ormerod, A Ormerod, AE Klon, AM Capelli, AR Leach, B Chen, Beining Chen, C Williams, D Hand, D Rogers, D Wilton, DA Cosgrove, David J. Wood, DB Kitchen, DE Clark, DJ Hand, DJ Wilton, DM Hawkins, E Parzen, FL Stahura, G Harper, G Redl, G Schneider, George Papadatos, H Eckert, H Kubinyi, HM Berman, J Aitchison, J Bajorath, J Delaney, J Hert, J Hert, J Hert, JC Saeh, L Hodes, L Hodes, L Hodes, M Congreve, M Glick, M Glick, M Wagener, M Whittle, N Christianini, N Nikolova, Nikolaus Stiefl, P Constans, P Domingos, P Willett, P Willett, P Willett, P Willett, P Willett, Paulette Greenidge, Peter Willett, Q Zhang, R P Sheridan, RD Brown, RD Brown, RD Cramer, RE Carhart, RO Duda, Robert F. Harrison, S Anzali, TJ McNeany, TM Mitchell, Xiao Qing Lewell, XY Xia, YC Martin, YC Martin   +71 more
core   +2 more sources