Results 31 to 40 of about 123,458 (267)

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

A review of the application of machine learning in water quality evaluation

Eco-Environment & Health, 2022
With the rapid increase in the volume of data on the aquatic environment, machine learning has become an important tool for data analysis, classification, and prediction.
Mengyuan Zhu, Jiawei Wang, Xiao Yang, Yu Zhang, Linyu Zhang, Hongqiang Ren, Bing Wu, Lin Ye   +7 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Spatial dynamics of bacterial community in chlorinated drinking water distribution systems supplied with two treatment plants: An integral study of free-living and particle-associated bacteria

Environment International, 2021
With the expansion of cities, the deterioration of drinking water quality undergoing complex and long-distance distribution is gaining increasing attention.
Kaiqin Bian, Chen Wang, Shuyu Jia, Peng Shi, Huaicheng Zhang, Lin Ye, Qing Zhou, Aimin Li   +7 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Facet effect of hematite on the hydrolysis of phthalate esters under ambient humidity conditions

Nature Communications, 2022
With a combined experimental and computational study, Jin et al. demonstrate that hematite nanoparticles can efficiently degrade phthalates under ambient humidity conditions, with a rate strongly dependent on the exposed facet via bidentate coordination ...
Xin Jin, Dingding Wu, Cun Liu, Shuhan Huang, Ziyan Zhou, Hao Wu, Xiru Chen, Meiying Huang, Shaoda Zhou, Cheng Gu   +9 more
doaj   +1 more source

Bayesian policy reuse [PDF]

Machine Learning, 2016
A long-lived autonomous agent should be able to respond online to novel instances of tasks from a familiar domain. Acting online requires 'fast' responses, in terms of rapid convergence, especially when the task instance has a short duration, such as in applications involving interactions with humans.
Benjamin Rosman, Majd Hawasly, Subramanian Ramamoorthy   +2 more
openaire   +5 more sources

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Characterization and evaluation of Fe2+ and Mn2+ in reservoirs and sediments in the Jianghuai Region

Scientific Reports
A dynamic monitoring study of water quality and sediment was conducted in August 2024 at four drinking water reservoirs in Hefei City (Dafangying, Dongpu, Modun, and Zhongxing Reservoirs).
Kun Wang, Wei Chen, Yuchao Tang, Beiping Zhang, Haixiang Sun, Changnian Wu, Jian Huang, Xianhuai Huang   +7 more
doaj   +1 more source