Results 41 to 50 of about 6,393,826 (325)

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

open access: yesFEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf   +6 more
wiley   +1 more source

Fe de erratas

open access: yesYachay, 2020
Fe de Erratas Yachay - Revista Científico Cultural, Vol. 8 (1) : 597-599, 2019. El manuscrito Participación indígena en el proceso de independencia desde los textos escolares.
editores rev Yachay
doaj   +1 more source

Reply to Comment on Dirac spectral sum rules for QCD in three dimensions [PDF]

open access: yes, 2000
I reply to the comment by Dr S. Nishigaki (hep-th/0007042) to my papers Phys. Rev. D61 (2000) 056005 and Phys. Rev.
C. Hilmoine   +5 more
core   +3 more sources

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

Analysis of coal permeability model and influencing parameters based on volume strain

open access: yesMeitan xuebao
To investigate the evolution of coal permeability during the process of gas pressure change, four different forms of permeability models were derived based on the correlation between mesoscale parameters of coal representative elementary volume (REV) and
Wei WANG   +6 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Регести документів польських архівосховищ про гетьмана Петра Сагайдачного та Хотинську війну 1621 р.

open access: yesНаукові записки НаУКМА: Історичні науки, 2022
У публікації подано 31 документ (переважно у вигляді регестів) з архівосховищ Польщі (Варшава, Вроцлав, Краків), що стосуються історії Хотинської війни і гетьмана Петра Конашевича-Сагайдачного – покровителя Києво-Могилянської академії, 400-ліття яких ...
Rev. Yurii Mytsyk
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

Comment on "Soliton ratchets induced by excitation of internal modes" [PDF]

open access: yes, 2004
Very recently Willis et al. [Phys. Rev. E {\bf 69}, 056612 (2004)] have used a collective variable theory to explain the appearance of a nonzero energy current in an ac driven, damped sine-Gordon equation.
Bernardo Sánchez-Rey   +3 more
core   +2 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

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