Nucleolar Localization of HIV-1 Rev Is Required, Yet Insufficient for Production of Infectious Viral Particles. [PDF]
, 2018 Combination antiretroviral therapy fails in complete suppression of HIV-1 due to drug resistance and persistent latency. Novel therapeutic intervention requires knowledge of intracellular pathways responsible for viral replication, specifically those ...
Arizala, Jerlisa Ann C +5 more
core +1 more source
Comment on "Classical and Quantum Interaction of the Dipole" [PDF]
, 2006 In this paper I have presented Comment on Anandan's paper (J. Anandan, Phys. Rev. Lett. 85, 1354 (2000)) [hep-th/9910018].Comment: 1 page, revtex; small changes, mainly typos, according to the published version in Phys.
J. D. Jackson, Tomislav Ivezić
core +3 more sources
eLife, 2014 The HIV-1 protein Rev controls a critical step in viral replication by mediating the nuclear export of unspliced and singly-spliced viral mRNAs. Multiple Rev subunits assemble on the Rev Response Element (RRE), a structured region present in these RNAs ...
Bhargavi Jayaraman +5 more
doaj +1 more source
Thermodynamics of Rev–RNA Interactions in HIV-1 Rev–RRE Assembly [PDF]
Biochemistry, 2015 The HIV-1 protein Rev facilitates the nuclear export of intron-containing viral mRNAs by recognizing a structured RNA site, the Rev-response-element (RRE), contained in an intron. Rev assembles as a homo-oligomer on the RRE using its α-helical arginine-rich-motif (ARM) for RNA recognition.
Jayaraman, Bhargavi +3 more
openaire +4 more sources
Pharmacological activation of the nuclear receptor REV-ERB reverses cognitive deficits and reduces amyloid-β burden in a mouse model of Alzheimer’s disease [PDF]
, 2019 Alzheimer’s disease currently lacks treatment options that effectively reverse the biological/anatomical pathology and cognitive deficits associated with the disease.
Burris, Thomas P +9 more
core +3 more sources
Mapping the binding interface between an HIV-1 inhibiting intrabody and the viral protein Rev. [PDF]
PLoS ONE, 2013 HIV-1 Rev is the key protein in the nucleocytoplasmic export and expression of the late viral mRNAs. An important aspect for its function is its ability to multimerize on these mRNAs.
Thomas Vercruysse +7 more
doaj +1 more source
Native mass spectrometry reveals the initial binding events of HIV-1 rev to RRE stem II RNA
Nature Communications, 2020 The HIV-1 RNA-binding protein rev facilitates nuclear export of viral RNA. Here, the authors use native mass spectrometry to study the interactions between rev-derived peptides and rev response elements of HIV-1 RNA, providing mechanistic insights into ...
Eva-Maria Schneeberger +8 more
doaj +1 more source
Retrovirology, 2007 Background The Sydney blood bank cohort (SBBC) of long-term survivors consists of multiple individuals infected with nef-deleted, attenuated strains of human immunodeficiency virus type 1 (HIV-1).
Wesselingh Steven L +3 more
doaj +1 more source
Impact of viral factors on subcellular distribution and RNA export activity of HIV-1 rev in astrocytes 1321N1. [PDF]
PLoS ONE, 2013 CNS associated cells are permissive to HIV-1 infection, but poor in virus production due to attenuated Rev activity. The temporal and the spatial distribution of Rev in human astrocyte 1321N1 and glioblastoma GO-G-CCM were monitored for explaining the ...
Atoshi Banerjee +2 more
doaj +1 more source
Comment on: `Pipe Network Model for Scaling of Dynamic Interfaces in Porous Media' [PDF]
, 2001 We argue that a proposed exponent identity [Phys. Rev. Lett 85, 1238 (2000)] for interface roughening in spontaneous imbibition is wrong. It rests on the assumption that the fluctuations are controlled by a single time scale, but liquid conservation ...
Ala-Nissila, T. +5 more
core +2 more sources