Results 41 to 50 of about 6,107,402 (271)
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Virology JournalBackground Reticuloendotheliosis virus (REV), a member of the family Retroviridae, is a hot area of research, and a previous study showed that exosomes purified from REV-positive semen were not blocked by REV-specific neutralizing antibodies and ...
Zhen Wang +5 more
doaj +1 more source
Nullbasic, a potent anti-HIV tat mutant, induces CRM1-dependent disruption of HIV rev trafficking.
PLoS ONE, 2012 Nullbasic, a mutant of the HIV-1 Tat protein, has anti-HIV-1 activity through mechanisms that include inhibition of Rev function and redistribution of the HIV-1 Rev protein from the nucleolus to the nucleoplasm and cytoplasm.
Min-Hsuan Lin +5 more
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A nucleolar localizing Rev binding element inhibits HIV replication
AIDS Research and Therapy, 2006 The Rev protein of the human immunodeficiency virus (HIV) facilitates the nuclear export of intron containing viral mRNAs allowing formation of infectious virions. Rev traffics through the nucleolus and shuttles between the nucleus and cytoplasm.
Bozzoni Irene +3 more
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Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Axial Nucleon to Delta transition form factors on 2+1 flavor hybrid lattices
, 2009 We correct the values of the dominant nucleon to Delta axial transition form factors CA_5 and CA_6 published in C. Alexandrou et.al., Phys. Rev. D 76,094511 (2007).
A. Tsapalis +5 more
core +1 more source
Reply to ``Comment on ``Lateral Casimir Force beyond the Proximity Force Approximation'' '' [PDF]
, 2007 We reply to the comment arXiv:quant-ph/0702060 on our letter arXiv:quant-ph/0603120 [Phys. Rev. Lett.
Astrid Lambrecht +4 more
core +3 more sources
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Tuning Rex rules HTLV-1 pathogenesis
Frontiers in Immunology, 2022 HTLV-1 is an oncovirus causing ATL and other inflammatory diseases such as HAM/TSP and HU in about 5% of infected individuals. It is also known that HTLV-1-infected cells maintain a disease-free, immortalized, latent state throughout the lifetimes of ...
Kazumi Nakano, Toshiki Watanabe
doaj +1 more source