Results 61 to 70 of about 6,107,402 (271)

Functional and structural segregation of overlapping helices in HIV-1

eLife, 2022
Overlapping coding regions balance selective forces between multiple genes. One possible division of nucleotide sequence is that the predominant selective force on a particular nucleotide can be attributed to just one gene.
Maliheh Safari, Bhargavi Jayaraman, Henni Zommer, Shumin Yang, Cynthia Smith, Jason D Fernandes, Alan D Frankel   +6 more
doaj   +1 more source

Comment on: Kinetic Roughening in Slow Combustion of Paper

, 1998
We comment on a recent Letter by Maunuksela et al. [Phys. Rev. Lett.
A.-L. Barabási, H. A. Makse, Hernán A. Makse, J. Maunuksela, J. Zhang, L. A. N. Amaral, L. A. N. Amaral, L.-H. Tang, Luís A. Nunes Amaral, M. Kardar, S. V. Buldyrev   +10 more
core   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Substitution of the Rev-response element in an HIV-1-based gene delivery system with that of SIVmac239 allows efficient delivery of Rev M10 into T-lymphocytes

AIDS Research and Therapy, 2008
Background Human immunodeficiency virus type 1 (HIV-1)-based gene delivery systems are popular due to their superior efficiency of transduction of primary cells.
Srinivasakumar Narasimhachar
doaj   +1 more source

Detection of bound entanglement in continuous variable systems [PDF]

, 2010
We present several entanglement conditions in order to detect bound entangled states in continuous variable systems. Specifically, Werner and Wolf [Phys. Rev. Lett. 86, 3658 (2001)] and Horodecki and Lewenstein [Phys. Rev. Lett.
Guo, Guang-Can, Nha, Hyunchul, Zhang, Cheng-Jie, Zhang, Yong-Sheng   +3 more
core   +3 more sources

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Comment on ``Stripe Glasses: Self-Generated Randomness in a Uniformly Frustrated System''

, 2001
comment on J. Schmalian and P. Wolynes, Phys. Rev. Lett. {\bf 85}, 836 (2000).Comment: 1 page, 1 Figure, accepted in Phys.
Grousson, M., Tarjus, G., Viot, P.
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Comment on "Spin-1 aggregation model in one dimension"

, 2001
M. Girardi and W. Figueiredo have proposed a simple model of aggregation in one dimension to mimic the self-assembly of amphiphiles in aqueous solution [Phys. Rev. E 62, 8344 (2000)].
D. Duque, Daniel Duque, H. Wennerström, J. de Moraes, J. Israelachvili, M. Girardi, M. Girardi   +6 more
core   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source