Results 111 to 120 of about 49,879 (288)

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

open access: yesMolecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou   +5 more
wiley   +1 more source

Isaiah 1:2−3 and Isaiah 6: Isaiah ‘a prophet like Moses’ (Dt 18:18)

open access: yesHTS Teologiese Studies/Theological Studies, 2012
The book of Isaiah is complex when one considers the reconstruction of the processes of its formation and transmission. If these complexities are examined more closely, it is apparent that there is a multiplicity of dimensions to the book.
Alphonso Groenewald
doaj  

Theological Affinities Between the Fourth Gospel and the Book of Revelation

open access: yesPerichoresis: The Theological Journal of Emanuel University
The focus of this study is on the exploration of theological affinities between the Fourth Gospel and Revelation. While I personally hold to the apostolic authorship of both writings by John, the son of Zebedee — admittedly a minority view in ...
Köstenberger Andreas J.
doaj   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham   +21 more
wiley   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

open access: yesMolecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan   +9 more
wiley   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

open access: yesMolecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts   +8 more
wiley   +1 more source

İmam Şâfiî’nin Fıkıh Usulünde Sünnet Vahiy İlişkisi

open access: yesEskiyeni, 2018
Bu makale, İmam Şâfiî’nin Hz. Peygamber’in Sünnetini vahiy olarak kabul etmesi konusunu ele almaktadır. O Sünnetin vahiy olduğunu iddia eder, çünkü Kuran bunu ifade etmekte ve inananlara da peygambere uymayı emretmektedir.
Ahmet Keleş
doaj  

Home - About - Disclaimer - Privacy