Results 151 to 160 of about 385,477 (311)

Inhibition of acyl‐CoA synthetase long‐chain isozymes decreases multiple myeloma cell proliferation and causes mitochondrial dysfunction

open access: yesMolecular Oncology, EarlyView.
Triacsin C inhibition of the acyl‐CoA synthetase long chain (ACSL) family decreases multiple myeloma cell survival, proliferation, mitochondrial respiration, and membrane potential. Made with Biorender.com. Multiple myeloma (MM) is an incurable cancer of plasma cells with a 5‐year survival rate of 59%.
Connor S. Murphy   +12 more
wiley   +1 more source

The Biais-Martimort-Rochet equilibrium with direct mechanisms [PDF]

open access: yes
In this note we show that the equilibrium characterized by Biais, Martimort and Rochet (Econometrica, 2000) could have been characterized by direct mechanisms even if the Revelation Principle does not apply in their setting. The use of more sophisticated
Gwenaël Piaser
core  

El relato de viaje de José María Guzmán por Oriente (1837): Entre construcción identitaria y palabra panfletaria

open access: yesCuadernos del CILHA
Con base en un postulado sociocrítico que sostiene que el objeto cultural es una producción socio-histórica, me propongo examinar la noción de revelación en un relato de viaje mexicano que data de la primera mitad del siglo XIX.
Assia Mohssine
doaj  

Vahiy Çeşitleri Tartışmalarında Kudsî Hadis Meselesi / The Issue of Hadith Qudsi in the Discussion on the Types of Revelation / مسألة الحديث القدسي في مناقشات أنواع الوحي

open access: yesİlahiyat Akademi, 2019
Kudsî hadis, mânası yüce Allah’a, lafzı ise Peygamber’e (s.a.v.) ait olan hadis olarak tanımlanmaktadır. Kudsî hadis olarak adlandırılan rivâyetlerin, vahyin hangi türüne dâhil olduğu, Kur’ân-ı Kerîm’den ve diğer nebevî hadislerden farklı olarak ne gibi ...
İsa Akalın
doaj  

Cell‐free DNA aneuploidy score as a dynamic early response marker in prostate cancer

open access: yesMolecular Oncology, EarlyView.
mFast‐SeqS‐based genome‐wide aneuploidy scores are concordant with aneuploidy scores obtained by whole genome sequencing from tumor tissue and can predict response to ARSI treatment at baseline and, at an early time point, to ARSI and taxanes. This assay can be easily performed at low cost and requires little input of cfDNA. Cell‐free circulating tumor
Khrystany T. Isebia   +17 more
wiley   +1 more source

Experts, Conflicts of Interest, and the Controversial Role of Reputation [PDF]

open access: yes
This paper studies the impact of reputation on the reporting strategy of experts that face conflicts of interest. The framework we propose applies to different settings involv- ing decision makers that rely on experts for making informed decisions, such ...
Filippo Pavesi, Massimo Scotti
core  

Integration of single‐cell and bulk RNA‐sequencing data reveals the prognostic potential of epithelial gene markers for prostate cancer

open access: yesMolecular Oncology, EarlyView.
Prostate cancer is a leading malignancy with significant clinical heterogeneity in men. An 11‐gene signature derived from dysregulated epithelial cell markers effectively predicted biochemical recurrence‐free survival in patients who underwent radical surgery or radiotherapy.
Zhuofan Mou, Lorna W. Harries
wiley   +1 more source

News About News: Information Arrival and Irreversible Investment [PDF]

open access: yes
We analyze how uncertainty about when information about future returns to a project may be revealed affects investment. While 'good news' about future returns boosts investment, 'good news about news' (that is news that information may arrive sooner) is ...
Allan Drazen, Plutarchos Sakellaris
core  

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

open access: yesMolecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin   +14 more
wiley   +1 more source

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