Results 31 to 40 of about 1,001,862 (295)

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Revenue management system for the hospitality [PDF]

Икономика и компютърни науки, 2017
The purpose of this study is to describe the essence of the revenue management system, applicable for entities in the hospitality industry, as a multidisciplinary concept, that draws its features from a variety of established academic areas, by ...
Kalinka Pavlova
doaj  

Real‐World Investigation of Satralizumab in Patients With Neuromyelitis Optica Spectrum Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Satralizumab, a monoclonal antibody targeting the interleukin‐6 receptor, has demonstrated efficacy in clinical trials for neuromyelitis optica spectrum disorder (NMOSD). However, its real‐world effectiveness and safety compared to conventional immunosuppressive therapies remain uncertain.
Li‐Tsung Lin, Hui‐An Lin, Sheng‐Feng Lin   +2 more
wiley   +1 more source

SHORT AND LONG-TERM PRICE ELASTICITY OF ROOM DEMAND-A TOOL FOR REVENUE MANAGEMENT: A HOTEL CASE STUDY IN BALI

Manajemen dan Bisnis, 2015
Room revenue is one of the biggest revenues in the hotel industry which is cited in the literature contributed 70-75% to total hotel revenue. Due to these roles, extant studies have been done in room revenue management.
Ida Bagus Made Wiyasha, I Nyoman Arcana
doaj   +1 more source

Maximising revenue for non-firm distributed wind generation with energy storage in an active management scheme [PDF]

, 2013
The connection of high penetrations of renewable generation such as wind to distribution networks requires new active management techniques. Curtailing distributed generation during periods of network congestion allows for a higher penetration of ...
Barbour, Edward, Gill, Simon, Infield, David, Wilson, I.A.Grant   +3 more
core   +1 more source

Age‐Related Characteristics of SYT1‐Associated Neurodevelopmental Disorder

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives We describe the clinical manifestations and developmental abilities of individuals with SYT1‐associated neurodevelopmental disorder (Baker‐Gordon syndrome) from infancy to adulthood. We further describe the neuroradiological and electrophysiological characteristics of the condition at different ages, and explore the associations ...
Sam G. Norwitz, Josefine Eck, Joel S. Winston, Kate Baker   +3 more
wiley   +1 more source

Management of Local Own-Source Revenue in Belu Government: A Phenomenological Study

Jurnal Ilmiah Akuntansi dan Bisnis, 2020
This study aims to explore the management of Original Local Government Revenue in the Belu District government with a phenomenological approach, namely an awareness study of the experience of the State Civil Apparatus in managing Original Local ...
Filemon Marselinus Taek, Ali Djamhuri, Zaki Baridwan   +2 more
doaj   +1 more source

Pricing and Revenue Management [PDF]

, 2009
The focus of this chapter is on the strategic role of price in revenue management (RM). In order to successfully use price as a strategic weapon, firms must address two questions: what prices to charge and how’ to determine which customers or market ...
Kimes, Sheryl E.
core   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Emotional labour, burnout and work engagement amongst service centre employees in South Africa

SA Journal of Human Resource Management
Orientation: Transforming public service delivery is crucial for the South African government. Emotional labour (EL), managing emotions during client interactions, is essential in service centres.
Amanda Erasmus, Elrie Oosthuysen
doaj   +1 more source