Results 31 to 40 of about 6,968,498 (295)
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
Econometrical Modelling of Profit Tax Revenue
Nonlinear Analysis: Modelling and Control, 2007 The aim of this article is to present a forecast of budget revenue from the profit tax using econometric models. The set of applied models has to be reduced to very simple models due to short time series used. Therefore, the profit tax regression analysis is made in two stages.
Rudzkis, Rimantas, Mačiulaitytė, Elena
openaire +6 more sources
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Other title: Business Income Modification
, 2017 "01/23/2017." Committee name taken from Kansas Legislature website. Information presented to the Kansas Legislature, Senate Committee on Assessment and Taxation, by the Office of Research and Analysis, Kansas Department of RevenueInformation giving ...
Kansas. Department of Revenue. Office of Policy and Research.
core +1 more source
THE IMPACT OF E-COMMERCE IN ON-LINE BUSINESS
Jurnal Analisis Bisnis Ekonomi, 2008 This research paper has aimed to-Commerce the first and the second waves, to find out the important role of E-Commerce in business, and to predict the future of E-Commerce. Those there issues will be the limination in this research paper. Since this is a
Rayna Kartika
doaj
Jurnal Public Policy, 2022 The sharing economy as a new business model is certainly a challenge for the Government to make policies related to this digital transaction. Governments are generally slow to accommodate new business models.
Vinda Laurencia Pangkey, Ning Rahayu
doaj +1 more source
Molecular Oncology, EarlyView.Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu +9 more
wiley +1 more source
UMYU Scientifica JournalTax revenue is a government's income from taxes imposed on individuals, businesses, and other entities. It is a crucial funding source for public expenditures, such as infrastructure, education, healthcare, security, and social services.
Musa Tasi’u +2 more
doaj +1 more source