Results 261 to 270 of about 95,587 (363)

ALKBH5‐Mediated M6A Demethylation of G3BP1 Attenuates Ferroptosis Via Cytoplasmic Retention of YBX1/p53 in Diabetic Myocardial Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
ALKBH5 promoted G3BP1 expression via m⁶A methylation at sites 142/173. G3BP1 interacts with YBX1 and p53, reducing their nuclear translocation and decreasing p53‐mediated SLC7A11 repression. This inhibites cardiomyocyte ferroptosis and mitigates myocardial damage during diabetic ischemia‐reperfusion injury.
Wenyuan Li, Wei Li, Yan Leng, Heng Xu, Zhongyuan Xia, Yao Wang   +5 more
wiley   +1 more source

Application of Hybrid Absorptive-Diffusive Panels with Variable Acoustic Characteristics Based on Wooden Overlays Designed Using Third-Degree-of-Freedom Bezier Curves. [PDF]

Materials (Basel)
Chojnacki B, Schynol K, Chojnacka K.
europepmc   +1 more source

LncRNA Foxo6os as a Novel “ Scaffold” Mediates MYBPC3 in Combating Pathological Cardiac Hypertrophy and Heart Failure

Advanced Science, EarlyView.
Schematic overview showing that forkhead box O6, opposite strand (Foxo6os) acts as a “scaffold”, directly binding myosin‐binding protein‐C (MYBPC3) and recruiting protein kinase C (PKC‐α) to mediate site‐specific phosphorylation of MYBPC3. This post‐translational modification supports cardiac contraction by regulating L‐type Ca2+ channels, especially ...
Jie Sheng, Qin Lin, Yizhuo Sun, Yilei Meng, Sangyu Hu, Huaming Cao, Fang Lin, Yuping Zhu, Luying Peng, Li Li   +9 more
wiley   +1 more source

The Auditory Environment at Early Intervention Groups for Young Children With Hearing Loss: Signal to Noise Ratio, Background Noise, and Reverberation. [PDF]

Ear Hear
Meijer A, Benard MR, Woonink A, Başkent D, Dirks E.   +4 more
europepmc   +1 more source

Targeting ROCK2 to Restore Epileptic Synaptic Networks via Mitophagy Activation: Insights from Translational Imaging of SV2A In Vivo

Advanced Science, EarlyView.
By integrating synaptic vesicle glycoprotein 2A PET imaging and transcriptomics, this study identifies Rho‐associated protein kinase 2 (ROCK2) as a critical regulator of synaptic network dysfunction in temporal lobe epilepsy. Pharmacological ROCK2 inhibition restores synaptic density and enhances mitophagy, thereby reducing seizures and neuronal damage.
Ling Xiao, Jing Wang, Bei Chen, Jinhui Yang, Fangyu Wu, Chunyao Zhou, Yifei Zhang, Zhiquan Yang, Dingyang Liu, Lei Tian, Jianhua Yu, Fei Han, Yongxiang Tang, Li Feng, Shuo Hu   +14 more
wiley   +1 more source

Impact of Reverberation on Speech Perception in Noise in Bimodal/Bilateral Cochlear Implant Users with and without Residual Hearing. [PDF]

J Clin Med
König C, Baumann U, Stöver T, Weissgerber T.   +3 more
europepmc   +1 more source

FOXM1 Protects Against Myocardial Ischemia‐Reperfusion Injury in Rodent and Porcine Models by Suppressing MKRN1‐Dependent LKB1 Ubiquitination

Advanced Science, EarlyView.
FOXM1 maintains mitochondrial bioenergetic function by inhibiting MKRN1‐mediated ubiquitination of LKB1 in cardiomyocytes. Loss of FOXM1 in cardiomyocytes results in upregulation of MKRN1, which enhances LKB1 ubiquitination and disrupts AMPK signaling and energy metabolism pathways. Conversely, FOXM1 overexpression preserves mitochondrial bioenergetics
Shuai Song, Xiaokai Zhang, Zihang Huang, Zhiqiang Pei, Linqi Zeng, Fengze Cai, Tongyao Wang, Mohan Li, Chenyan Liu, Yining Song, Jiahao Guo, Hao Lu, Xinyu Weng, Li Shen, Xiaochun Zhang, Xingxing Cai, Aijun Sun, Junbo Ge   +17 more
wiley   +1 more source

Acoustic scene complexity affects motion behavior during speech perception in audio-visual multi-talker virtual environments. [PDF]

Sci Rep
Slomianka V, Dau T, Ahrens A.
europepmc   +1 more source

Joint Late Reverberation and Noise Power Spectral Density Estimation in a Spatially Homogeneous Noise Field

IEEE International Conference on Acoustics, Speech, and Signal Processing, 2018
I. Kodrasi, S. Doclo
semanticscholar   +1 more source

Solvent Replacement‐Driven Ionic Liquid Thermoelectric Gel for Self‐Powered Morse Code Communication Assisted by Machine Learning

Advanced Science, EarlyView.
A solvent replacement method is employed to transform PMAA hydrogel into a PMAA IL gel. The assembled thermoelectric device demonstrated stable voltage output and temperature sensitivity across a wide operating temperature range. Additionally, a self‐powered communication system integrating the PMAA IL gel with a logistic regression model is developed,
Lingshuang Kong, Fengrui Zhao, Jing Li, Fanlun Meng, Wenlong Xu   +4 more
wiley   +1 more source