Results 51 to 60 of about 60,417 (275)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Toward Precision Measurement of Central Black Hole Masses

, 2010
We review briefly direct and indirect methods of measuring the masses of black holes in galactic nuclei, and then focus attention on supermassive black holes in active nuclei, with special attention to results from reverberation mapping and their ...
Bradley M. Peterson, Collin, Pastorini
core   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Reverberation suppression using non-negative matrix factorization to detect low-Doppler target with continuous wave active sonar

EURASIP Journal on Advances in Signal Processing, 2019
In active sonar systems, the detection of echo from targets can deteriorate due to reverberation. Detection becomes more difficult if targets have low-Doppler frequency and are located near the reverberation band, especially in an environment with low ...
Seokjin Lee, Jun-seok Lim
doaj   +1 more source

Hierarchical Reverberation Mapping

, 2013
Reverberation mapping (RM) is an important technique in studies of active galactic nuclei (AGN). The key idea of RM is to measure the time lag $\tau$ between variations in the continuum emission from the accretion disc and subsequent response of the ...
Brewer, Brendon J., Elliott, Tom M.
core   +1 more source

Revisiting Mission‐Oriented Cancer Research to tackle the increasing burden of cancer in Europe–a policy perspective

Molecular Oncology, EarlyView.
Translational cancer research and its implementation through competitively selected Comprehensive Cancer Centers across Europe should be the primary policy focus for addressing the increasing cancer burden in Europe and counteract the present main strategy to convert cancer to a chronic disease.
Manuel Heitor, Julio Celis, Ulrik Ringborg   +2 more
wiley   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

The Acoustics of the Double Elliptical Vault of the Royal Palace of Caserta (Italy)

Buildings, 2017
This work investigates the acoustic characteristics of the double elliptical vault, which overlooks the Grand Staircase of the Royal Palace of Caserta (Italy). The Royal Palace was built by the architect Luigi Vanvitelli in the Seventeenth Century and it
Umberto Berardi, Gino Iannace, Amelia Trematerra   +2 more
doaj   +1 more source

The Lick AGN Monitoring Project 2011: Reverberation Mapping of Markarian 50 [PDF]

, 2011
The Lick AGN Monitoring Project 2011 observing campaign was carried out over the course of 11 weeks in Spring 2011. Here we present the first results from this program, a measurement of the broad-line reverberation lag in the Seyfert 1 galaxy Mrk 50 ...
Assef, R. J., Bae, H. -J., Barth, A. J., Bennert, V. N., Brewer, B. J., Buehler, T., Canalizo, G., Cenko, S. B., Clubb, K. I., Cooper, M. C., da Silva, R. L., Diamond-Stanic, A. M., Filippenko, A. V., Fumagalli, M., Gates, E. L., Greene, J. E., Gregg, M. D., Harris, C. E., Hiner, K. D., Hoenig, S. F., Hsiao, E. Y., Joner, M. D., Kandrashoff, M. T., Laney, C. D., Lazarova, M. S., Lee, J., Li, W., Lopez, L., Malkan, M. A., Nierenberg, A. M., Pancoast, A., Park, D., Rex, J., Sand, D. J., Silverman, J. M., Son, D., Sonnenfeld, A., Stern, D., Suzuki, N., Thorman, S. J., Tollerud, E. J., Treu, T., Trump, J. R., Tytler, D., Walsh, J. L., Walters, R., Woo, J. -H., Worseck, G., Yesuf, H. M.   +48 more
core   +3 more sources

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source