Results 71 to 80 of about 494,147 (304)

Reversal of type 2 diabetes through metabolic restoration: A narrative review

open access: yesJournal of Metabolic Health
Background: Type 2 diabetes (T2D) is traditionally managed as an irreversible disease with escalating polypharmacy. However, evidence increasingly shows that durable remission is achievable.
Salah Snouda
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

open access: yesFEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

The simple failure of Curie's Principle [PDF]

open access: yes, 2012
This note points out a simple sense in which the standard formulation of Curie’s Principle is false, when the symmetry transformation it describes is time ...
Roberts, Bryan W., Bryan W. Roberts
core   +1 more source

Causal Reversibility Implies Time Reversibility

open access: yes, 2023
Several notions of reversibility exist in the literature. On the one hand, causal reversibility establishes that an action can be undone provided that all of its consequences have been undone already, thereby making it possible to bring a system back to a past consistent state.
M. Bernardo   +5 more
openaire   +5 more sources

A Comparative Analysis of Overnight vs. Daytime Static and Momentum Strategies Across Sector ETFs

open access: yesRisks
This study examines overnight vs. daytime static and momentum strategies applied to ten sector Exchange-traded funds (ETFs) over a 27-year period from 1999 to 2025.
Gourav Salotra   +3 more
doaj   +1 more source

Studi Retrospektif: Reaksi Kusta Tipe 1

open access: yesBerkala Ilmu Kesehatan Kulit dan Kelamin (Periodical of Dermatology and Venerology), 2019
Latar Belakang: Reaksi kusta tipe 1 terjadi akibat perubahan keseimbangan antara cell mediated immunity (CMI) dan basil Mycobacterium leprae di saraf dan kulit pasien kusta dengan hasil akhir berupa upgrading atau reversal.
Ridha Ramadina Widiatma   +1 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

open access: yesFEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas   +4 more
wiley   +1 more source

A New Type of Preference Reversal [PDF]

open access: yes
The classic preference reversal phenomenon arises in a comparison between a choice and a matching task. We present a new type of preference reversal which is entirely choice-based.
Jose Luis Pinto-Prades, Han Bleichrodt
core  

Effect of lanosterol on human cataract nucleus

open access: yesIndian Journal of Ophthalmology, 2015
Aim: To study the effect of lanosterol on age-related cataractous human lens nuclei. Materials and Methods: Forty age-related cataractous nuclei removed during manual small incision cataract surgery were obtained and randomly immersed in 25 mM lanosterol
P Mahesh Shanmugam   +6 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

open access: yesFEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang   +2 more
wiley   +1 more source

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