Results 61 to 70 of about 494,147 (304)
TH Open, 2019 Idarucizumab is a humanized antigen binding fragment (Fab) of a recombinant anti-dabigatran monoclonal antibody (IgG1-kappa) that allows rapid and sustained reversal of dabigatran-induced anticoagulation in case of bleeding or urgent surgery.
Nicolas Gendron +5 more
doaj +1 more source
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Reversible Computation vs. Reversibility in Petri Nets [PDF]
Science of Computer Programming, 2016 Abstract Petri nets are a general formal model of concurrent systems which supports both action-based and state-based modelling and reasoning. One of important behavioural properties investigated in the context of Petri nets has been reversibility, understood as the possibility of returning to the initial marking from any reachable net marking.
Kamila Barylska +3 more
openaire +3 more sources
Pharmacology Research & Perspectives, 2022 Opioid‐induced respiratory depression (OIRD) is a potentially life‐threatening complication of opioid consumption. Apart from naloxone, an opioid antagonist that has various disadvantages, a possible reversal strategy is treatment of OIRD with the ...
Marieke Hyke Algera +8 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
La douleur comme « matrice » de la vie intérieure chez Nietzsche [PDF]
Meta: Research in Hermeneutics, Phenomenology and Practical Philosophy, 2011 This paper attempts to put some order among the different notions of pain that are to be found in the Nietzschean philosophical corpus. It tries to show that there is a mutation of the Nietzschean concept of pain, from the notion of pain as evaluation to
Ciprian Jeler
doaj
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
grillfilip/Dopamine-release-in-human-associative-striatum-during-reversal-learning: Imaging data
, 2023 <p><strong>Full Changelog</strong>: https://github.com/grillfilip/Dopamine-release-in-human-associative-striatum-during-reversal-learning/compare/Imagingdata...NatComReleaseImaging</p ...
grillfilip
core +1 more source
Towards Reverse Engineering Reversible Logic
CoRR, 2017 Reversible logic has two main properties. First, the number of inputs is equal to the number of outputs. Second, it implements a one-to-one mapping; i.e., one can reconstruct the inputs from the outputs. These properties enable its applications in building quantum computing architectures.
Samah Mohamed Saeed +6 more
openaire +2 more sources