Results 91 to 100 of about 657,530 (303)

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Experimental Test of the State Estimation-Reversal Tradeoff Relation in General Quantum Measurements

Physical Review X, 2014
When a measurement has limited strength, only partial information, regarding the initial state, is extracted, and, correspondingly, there is a probability to reverse its effect on the system and retrieve the original state.
Geng Chen, Yang Zou, Xiao-Ye Xu, Jian-Shun Tang, Yu-Long Li, Jin-Shi Xu, Yong-Jian Han, Chuan-Feng Li, Guang-Can Guo, Hai-Qiao Ni, Ying Yu, Mi-Feng Li, Guo-Wei Zha, Zhi-Chuan Niu, Yaron Kedem   +14 more
doaj   +1 more source

Observation of a large parity nonconserving analyzing power in Xe

, 1996
A large parity nonconserving longitudinal analyzing power was discovered in polarized-neutron transmission through Xe. An analyzing power of 4.3±0.2% was observed in a p-wave resonance at En=3.2 eV.
Bowman, J D, Cain, B, Crawford, Bret E., Delheij, P P J, Hartman, R D, Haseyama, T, Keith, C D, Knudsen, J N, Komives, A, Leuschner, M, Lowie, L Y, Masaike, A, Matsuda, Y, Mitchell, G E, Penttila, S I, Postma, H, Rich, D, Roberson, N R, Seestrom, S J, Sharapov, E I, Snow, W M, Stephenson, Sharon L., Szymanski, J J, Yen, Y-F, Yuan, V W   +24 more
core   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Higher Sex‐Reversal Rate of Urban Frogs in a Common‐Garden Experiment Suggests Adaptive Microevolution

Evolutionary Applications
Ectothermic vertebrates with genotypic sex determination may adjust their sexual phenotype to early‐life environmental conditions by sex reversal, and theoretical models predict diverse consequences for population dynamics and microevolution under ...
Veronika Bókony, Emese Balogh, Zsanett Mikó, Andrea Kásler, Zoltán Örkényi, Nikolett Ujhegyi   +5 more
doaj   +1 more source

Symmetry Considerations for the Detection of Second-Harmonic Generation in Cuprates in the Pseudogap phase

, 2002
A proposal to test the proposed time-reversal and inversion breaking phase in the Pseudogap region of the Cuprate compounds through the variation of Second-harmonic generation intensity with temperature and polarization and angle of incidence is ...
A. Kaminski, C. M. Varma, C.M. Varma, C.M. Varma, C.M. Varma, C.M. Varma, M. E. Simon, M. Fiebig, M.E. Simon   +8 more
core   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Shunt Diode Designs in Li/cf Shuttle Batteries [PDF]

, 1984
Although Li/CF cells and batteries have an excellent safety record, they are included with other battery systems that require additional safety precautions. One precaution suggested is the inclusion of shunt diodes into these batteries.
Higgins, R., Miller, D.
core   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Study of the $K_SK_L\to\pi\ell\nu 3 \pi^0$ process for time reversal symmetry test at KLOE-2

, 2015
This work presents prospects for conducting a novel direct test of time-reversal symmetry at the KLOE-2 experiment. Quantum entanglement of neutral K meson pairs uniquely available at KLOE-2 allows to probe directly the time-reversal symmetry (T ...
Gajos, Aleksander
core   +1 more source