Results 71 to 80 of about 23,572,323 (347)

OBESITY, SES, AND ECONOMIC DEVELOPMENT: A TEST OF THE REVERSAL HYPOTHESIS

open access: yesSocial Science & Medicine (1967), 2012
Studies of individual countries suggest that socioeconomic status (SES) and weight are positively associated in lower-income countries but negatively associated in higher-income countries.
Fred C. Pampel   +2 more
semanticscholar   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

Cognition in the field: comparison of reversal learning performance in captive and wild passerines

open access: yesScientific Reports, 2017
Animal cognitive abilities have traditionally been studied in the lab, but studying cognition in nature could provide several benefits including reduced stress and reduced impact on life-history traits.
M. Cauchoix   +3 more
semanticscholar   +1 more source

Synaptic GABA release prevents GABA transporter type-1 reversal during excessive network activity. [PDF]

open access: yes, 2015
GABA transporters control extracellular GABA, which regulates the key aspects of neuronal and network behaviour. A prevailing view is that modest neuronal depolarization results in GABA transporter type-1 (GAT-1) reversal causing non-vesicular GABA ...
Rusakov, Dmitri A.   +9 more
core   +1 more source

Structure‐forward targeting of claudins with synthetic binders

open access: yesFEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Item - Test Alternate Title

open access: yes
Item - Test Description ...
Item - Test Creator 1   +2 more
core   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

open access: yesFEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas   +4 more
wiley   +1 more source

Pengaruh ukuran perusahaan, bid ask spread, dan volume perdagangan terhadap price reversal

open access: yesPerformance, 2017
Purpose: “The Influence of Firm Size, Bid Ask Spread, and Trading Volume on Price Reversal” is a research that aims to analyze the factors that affect price reversal on companies listed in LQ45 Index in period of November 8 - November 16, 2016 ...
Flora Sianipar   +2 more
doaj  

Optimised reversal without train-of-four monitoring versus reversal using quantitative train-of-four monitoring: An equivalence study

open access: yesIndian Journal of Anaesthesia, 2019
Background and Aims: Less residual paralysis in recovery room was demonstrated when train-of-four (TOF) monitoring was applied. The aim of this study was to know whether optimisation of neostigmine reversal without TOF monitoring was equivalent to ...
Ardyan Wardhana   +2 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

open access: yesFEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang   +2 more
wiley   +1 more source

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