Results 111 to 120 of about 657,530 (303)
Molecular Oncology, EarlyView.This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad +17 more
wiley +1 more source
An Angular Correlation Test of Time Reversal Invariance [PDF]
Gamma-ray angular correlation experiment of time reversal ...
Casper, K. J., Kuebbing, R. A.
core +1 more source
Reverse score and likelihood ratio tests [PDF]
, 1999 Two extensions of a parametric model are proposed, each one involving the score function of an alternative parametric model. We show that the encompassing hypothesis is equivalent to standard conditions on the score of each of the extended models.
Dhaene, Geert, Scaillet, Olivier
openaire +4 more sources
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
BOLTS PULLING TEST. REVERSER FOR BOLTS TESTING
International Journal for Computational Civil and Structural Engineering, 2018 The article describes developed device for performing pulling tests of bolts, including high-strength. Principle of reverser operation is change of sign of applied load – compression of press causes stretching of a bolt. Advantages of presented reverser are: reliability, mobility, small size, economical operation and simpleness. Reverser designs permit
openaire +2 more sources
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
Survivin and Aurora Kinase A control cell fate decisions during mitosis
Molecular Oncology, EarlyView.Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir +2 more
wiley +1 more source
In search of a preferred preference elicitation method: A test of the internal consistency of choice and matching tasks [PDF]
The numerous reports on preference reversals in preference elicitations pose a great challenge to empirical economics. Many studies have found that different procedures may generate substantially different preferences.
Attema, Arthur, Brouwer, Werner
core +1 more source
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
CREDIT SCORE MIGRATION ANALYSIS OF FARM BUSINESSES: CONDITIONING ON BUSINESS CYCLES AND MIGRATION TRENDS [PDF]
This study examines credit score migration rates of farm businesses. We test whether migration probabilities differ across business cycles. Our results suggest that agricultural credit ratings are more likely to improve during expansions and deteriorate ...
Katchova, Ani L., Phillips, Jill
core +1 more source