Results 201 to 210 of about 195,756 (266)

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Negative-pressure wound therapy versus conventional dressings following stoma reversal: a GRADE-based systematic review and meta-analysis of randomized controlled trials with predefined subgroup analyses by closure technique. [PDF]

BMC Surg
Mirza W, Khan ME, Iqbal H, Khan A, Khan HM, Moeen-Ud-Din MB, Hadhoud AM.   +6 more
europepmc   +1 more source

Adenosine triphosphate as a modulator of protein interactions and stability

FEBS Open Bio, EarlyView.
ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley   +1 more source

The Impacts of Pregnancy on Cognition and Cell Proliferation in a Live-Bearing Fish (Poeciliopsis gracilis). [PDF]

Eur J Neurosci
Ernst TR, Keijzer A, Vellere S, Lee A, van Leeuwen JL, Kotrschal A, Korosi A, Pollux BJA.   +7 more
europepmc   +1 more source

Distinct mechanisms of replication stress induced by oncogenic RAS and cyclin E1 converge on R-loop-dependent fork reversal. [PDF]

Nat Commun
Oravetzova A, Dvorakova M, Mihai AI, Andrs M, Sobol M, Zuev A, Shukla K, Boleslavska B, Rosano V, König C, Prokes J, Hanzlikova H, Macurek L, Dobrovolna J, Janscak P.   +14 more
europepmc   +1 more source

Excessive Apixaban Concentrations in a Bleeding Patient Treated With Pharmacological Reversal and Extracorporal Removal-A Case Report. [PDF]

Pharmacol Res Perspect
Kraus RF, Rosenberger J, Dejaco A, Paal M, Hart C, Burkhardt R, Kees MG.   +6 more
europepmc   +1 more source

CRF Receptor Type 1 Modulates the Nigrostriatal Dopamine Projection and Facilitates Cognitive Flexibility after Acute and Chronic Stress. [PDF]

eNeuro
Becchi S, Burton CL, Tsoukalas M, Bowring J, Balleine BW, Mor D.   +5 more
europepmc   +1 more source

Seeking the Mechanism for Reversal of Enhanced Insulin Sensitivity After Acute Exercise. [PDF]

Exerc Sport Sci Rev
Wang H, Cartee GD.
europepmc   +1 more source

Low anterior resection syndrome after sphincter-preserving surgery for rectal cancer: predictive factors and impact on perceived functional satisfaction. [PDF]

Discov Oncol
Suraga B, Nayak SP, Gangadhara B, Reddy S, Khan A, Munisiddaiah D, Vinodhini P, H Biral V, Janakiraman SS, Ranganathan K.   +9 more
europepmc   +1 more source