Results 141 to 150 of about 1,985,009 (249)

Risk factors for occurrence of reverse pupillary block after intraocular lens fixation surgery. [PDF]

J Cataract Refract Surg
Yuma M, Jujo T, Sato K, Sekine R, Fujita N, Uchiyama N, Kakehashi K, Endo A, Tokuda N, Kitaoka Y.   +9 more
europepmc   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Statistical Fragility of Randomized Control Trials Comparing Surgical and Conservative Management of Distal Radius Fractures in Elderly Patients. [PDF]

Hand (N Y)
Campa-Maldonado CM, Acosta-Julbe JI, Guzmán-Gutierrez J, Silva-Aponte JA, Foy-Parrilla C.   +4 more
europepmc   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Vine-Inspired Twining Actuator: Cylindrical Hyper-Form-Closure Envelopment by Single Actuated Linkage. [PDF]

Biomimetics (Basel)
Liao J, Zhou Q, Wang Y, Chen J, Luo Y, Liu G, Chen M, Zhang C, Zhao J.   +8 more
europepmc   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Skin bacteriota ameliorates androgenetic alopecia via harmonizing skin immuno inflammatory balance. [PDF]

Braz J Microbiol
Cao Y, Wu X, Huang Z, Xu C, Ge Z, Xie Y, Wu L, Qian Y, Ding B, Luo H.   +9 more
europepmc   +1 more source

Reversed Parentectomy [PDF]

Journal of Asthma Research, 1970
openaire   +2 more sources

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Rapid and Visual Detection of Muscovy Duck Reovirus Using a Reverse Transcription Recombinase-Aided Amplification Assay in a Lyophilized Format for Point-of-Care Applications. [PDF]

Transbound Emerg Dis
Chen X, Zhang S, Luo X, You G, Chen S, Huang M, Wang S, Chen S.   +7 more
europepmc   +1 more source