Results 61 to 70 of about 2,040,555 (269)
Місто: історія, культура, суспільство, 2019 In the paper, the historiography of the problem is examined. The critique of the privet paper money which was circulating in the Ukrainian lands in 1917–1921 is conducted.
Yevheniya Shyshkina, Yaroslav Motenko
doaj +1 more source
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Causal Reversibility Implies Time Reversibility
, 2023 Several notions of reversibility exist in the literature. On the one hand, causal reversibility establishes that an action can be undone provided that all of its consequences have been undone already, thereby making it possible to bring a system back to a past consistent state.
M. Bernardo +5 more
openaire +5 more sources
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Journal of Inequalities and Applications, 2016 By applying the weight functions, the technique of real analysis and Hermite-Hadamard’s inequality, a half-discrete Hardy-Hilbert-type inequality related to the kernel of exponential function with the best possible constant factor expressed by the gamma ...
Jianquan Liao, Bicheng Yang
doaj +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
To reverse or to not reverse Likert-type items: That is the question
Psicothema, 2020 The suitability of using reversed items in typical response measures has been a matter of controversy for many years. While some authors recommend their use, others reject them due to their undesirable effects on tests' psychometric properties. The present research intends to analyse a third alternative based on the use of reversed items plus a ...
Vigil Colet, Andreu +2 more
openaire +3 more sources
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source