Donor‐derived tdTomato+ mature hepatocytes were FACS‐isolated and transplanted into Fah−/− host mice. During regeneration, these cells convert into proliferative, unipotent Afp+ rHeps. Their plasticity is governed by a PPARγ/AFP‐dependent metabolic switch, segregating into pro‐proliferative Afplow and pro‐survival Afphigh subpopulations.
Ting Fang +12 more
wiley +1 more source
Amelioration of atherosclerotic complications and dyslipidemia by verbascoside-enriched fraction of <i>Clerodendrum glandulosum</i> leaves targeting LDL-R and LXR-mediated reverse cholesterol transport. [PDF]
Khound P, Gurumayum N, Devi R.
europepmc +1 more source
Sodium salicylate rewires hepatic metabolic pathways in obesity and attenuates IL-1β secretion from adipose tissue: The implications for obesity-impaired reverse cholesterol transport. [PDF]
Kajani S +9 more
europepmc +1 more source
Membrane‐Mediated Force Transduction Drives Stick‐Slip Motion of Lipid Vesicles
A rotating magnetic field actuates a ferromagnetic particle inside a lipid vesicle, generating internal flows that induce stick‐slip propulsion near a surface. Membrane properties—elasticity, excess area, and phase behavior—modulate this motion by shaping stress dissipation and force transduction.
Paula Magrinya +3 more
wiley +1 more source
Ellagic acid, a functional food component, ameliorates functionality of reverse cholesterol transport in murine model of atherosclerosis. [PDF]
Park SH +5 more
europepmc +1 more source
Putting cholesterol in its place: apoE and reverse cholesterol transport [PDF]
Robert W. Mahley
openalex +1 more source
Integrin β3 Orchestrates Hepatic Steatosis via a Novel CD36‐Dependent Lipid Uptake Complex
In MASH, ITGB3 recruits LYN and drives its ubiquitin‐proteasomal degradation via phosphorylation. This relieves DHHC5 inhibition, enabling ITGB3/DHHC5/CD36 complex assembly to enhance CD36 palmitoylation and fatty acid uptake, thereby exacerbating disease. Targeting ITGB3 blocks this pathogenic axis and ameliorates MASH.
Ying Zhang +13 more
wiley +1 more source
The roles of nuclear receptors in cholesterol metabolism and reverse cholesterol transport in nonalcoholic fatty liver disease. [PDF]
Li Z +8 more
europepmc +1 more source

