Results 71 to 80 of about 10,576 (266)

Dual‐Input High Step‐Up Boost‐SEPIC Converter With Common Ground

IET Renewable Power Generation
This paper proposes a dual‐input single‐output high step‐up converter for use in renewable energy systems. In this converter, the boost and SEPIC structures are integrated.
Shahriar Khatibi Nejad, Mohammad Rouhollah Yazdani, Majid Delshad, Mahdi Sajadieh   +3 more
doaj   +1 more source

An Improved Zero Current Transition High Step-Up Single-Switch Converter for Fuel Cell Applications [PDF]

Hydrogen, Fuel Cell & Energy Storage
In this sudy, a new high step-up converter with reduced input current ripple and low voltage stress is presented. The converter features a minimal number of components, leading to reduced volume and cost.
Rasol Sareban, Mohammadreza Amini, Majid Delshad, Mohammad Rouhollah Yazdani   +3 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

HVDC converter simulation model with turn-off characteristics of series thyristors

International Journal of Electrical Power & Energy Systems
The converter models in common electromagnetic transient simulation software cannot reflect the dynamic turn-off process and the dispersity of series thyristors, which leads to inaccurate judgment and simulation of the commutation failure (CF).
Yupeng He, Yechun Xin, Guoqing Li, Tuo Wang, Shouqi Jiang, Weiru Wang, Yanxu Wang   +6 more
doaj   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

High Step-Up DC–DC Converter With Low Switch Voltage Stress, Continuous Input Current, and ZVS Operation

IEEE Open Journal of Power Electronics
This article introduces a new fully soft switched ultra-high step-up quadratic converter. The proposed converter benefits from several advanced features including high voltage gain at low duty cycle, low switch voltage stress, low sum of diodes voltage ...
Maryam Hajilou, Hosein Farzanehfard, Hani Vahedi   +2 more
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source