Results 141 to 150 of about 1,069,867 (309)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Applying Revenue Management to the Reverse Supply Chain
We study the disposition decision for product returns in a closed-loop supply chain. Motivated by the asset recovery process at IBM, we consider two disposition alternatives.
Fleischmann, M. +2 more
core +1 more source
Research on the Temperature Characteristics of 1 200 V 4H-SiC Junction Barrier Schottky Diode
Kongzhi Yu Xinxi Jishu, 2016 In order to research the effect of temperature on static electrical parameters of 4H–SiC junction barrier Schottky (JBS) diode,1.2 kV 4H–SiC JBS diodes were fabricated and their current-voltage characteristics were measured in the range of 25 ℃ ~150 ...
YUAN Hao +5 more
doaj
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
The effect of mode of current on reverse iontophoresis
, 2003 Paper discussing the effect of mode of current on reverse ...
Connolly, P. +2 more
core
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Reverse Current Model for Coronal Mass Ejection Cavity Formation [PDF]
, 2018 We report here a new model for explaining the three-part structure of coronal mass ejections (CMEs). The model proposes that the cavity in a CME forms because a rising electric current in the core prominence induces an oppositely directed electric ...
Bellan, Paul M. +3 more
core
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Study on the reverse characteristics of Ti/6H-SiC Schottky contacts
, 2003 The reverse I(V) measurement and analytic calculation of the electron transport across a Ti/6H-SiC Schottky barrier are presented. Based on the consideration of the barrier fluctuations and the barrier height shift caused by image charge and the applied ...
Shang YC,Chinese Acad Sci,Microelect R&D Ctr,Inst Semicond,Beijing 100083,Peoples R China. +3 more
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