Results 71 to 80 of about 3,284,407 (297)
Molecular bases of circadian magnesium rhythms across eukaryotes
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley +1 more source
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
Imaging spectroscopy with the atomic force microscope [PDF]
Force curve imaging spectroscopy involves acquiring a force-distance curve at each pixel of an atomic force microscope image. Processing of the resulting data yields images of sample hardness and tip-sample adhesion.
Baldeschwieler, John D. +1 more
core +1 more source
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Channel-Width Dependent Enhancement in Nanoscale Field Effect Transistor [PDF]
We report the observation of channel-width dependent enhancement in nanoscale field effect transistors containing lithographically-patterned silicon nanowires as the conduction channel. These devices behave as conventional metal-oxide-semiconductor field-
Chen, Yu +4 more
core
Informal Jobs and Trade Liberalisation in Argentina [PDF]
Rapid trade liberalisation can exert profound effects on labour markets. Domestic firms, to sustain competitiveness for survival, could react through cutting labour benefits to achieve cost reductions.
Acosta, P., Montes-Rojas, G.
core +3 more sources
The reversal effect of prohibition signs [PDF]
In public places one encounters many prohibition signs, as well as traces of the norm-violating behavior these signs are trying to reduce, like graffiti or litter. Based on goal framing theory and previous research, we argue that signs of (dis)respect of others for norms serve as norm-support cues which can weaken or strengthen the influence of norms.
Keizer, Kees +2 more
openaire +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
The impact of experience on the tendency to accept recommended defaults
Two preregistered web studies are presented that explore the impact of experience on the tendency to accept recommended defaults. In each of the 100 trials, participants (n = 180, n = 165) could accept a recommended default option or choose a less ...
Yefim Roth +2 more
doaj +1 more source
Reversing the endowment effect
AbstractWhen given a desirable item, people have a tendency to value this owned item more than an equally-desirable, unowned item. Conversely, when the endowed item is undesirable, in some circumstances people have a tendency to swap it for an equally undesirable item, a phenomenon known as the reversed endowment effect.
Campbell Pryor +2 more
openaire +3 more sources

