Results 51 to 60 of about 952,555 (291)
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Learning reversible symplectic dynamics
, 2022 Time-reversal symmetry arises naturally as a structural property in many dynamical systems of interest. While the importance of hard-wiring symmetry is increasingly recognized in machine learning, to date this has eluded time-reversibility. In this paper we propose a new neural network architecture for learning time-reversible dynamical systems from ...
Valperga, R +4 more
openaire +3 more sources
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Bending the learning curve [PDF]
, 2015 This paper aims at improving the application of the learning curve, a popular tool used for forecasting future costs of renewable technologies in integrated assessment models (IAMs). First, we formally discuss under what assumptions the traditional (OLS)
Tavoni, Massimo +2 more
core +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
A general software defect-proneness prediction framework [PDF]
, 2011 This is the author's accepted manuscript. The final published article is available from the link below. Copyright @ 2011 IEEE. Personal use of this material is permitted.
Jia, Z +4 more
core +1 more source
Tumor mutational burden as a determinant of metastatic dissemination patterns
Molecular Oncology, EarlyView.This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal +4 more
wiley +1 more source
Journal of International StudentsThis paper examines the impact of senior influencers on Douyin and their role in shaping the educational perceptions of postgraduate students in mainland China. The paper comprises 23 semistructured interviews with students in Guangdong, exploring three themes: algorithm-driven intergenerational identity fluidity, the decentralization of knowledge ...
Wenrui Liang +3 more
openaire +1 more source
Deep Unsupervised Learning using Nonequilibrium Thermodynamics [PDF]
, 2015 A central problem in machine learning involves modeling complex data-sets using highly flexible families of probability distributions in which learning, sampling, inference, and evaluation are still analytically or computationally tractable.
Ganguli, Surya +3 more
core
Unsupervised Incremental Learning of Deep Descriptors From Video Streams
, 2017 We present a novel unsupervised method for face identity learning from video sequences. The method exploits the ResNet deep network for face detection and VGGface fc7 face descriptors together with a smart learning mechanism that exploits the temporal ...
Del Bimbo, Alberto, Pernici, Federico
core +1 more source