Results 51 to 60 of about 2,929 (285)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Clinical Significance of Therapeutic Drug Level Monitoring for Mycophenolate in Patients With Extrarenal Systemic Lupus Erythematosus—A Systematic Review and Meta‐Analysis

Arthritis Care &Research, EarlyView.
Objective Clinical response to mycophenolic acid (MPA) is highly heterogeneous; thus, therapeutic drug level monitoring (TDM) may help improve treatment efficacy. This systematic review and meta‐analysis examined therapeutic ranges for MPA levels associated with better outcomes and safety in patients with systemic lupus erythematosus (SLE ...
Zahraa Qamhieh, Dalia Sriwi, Callie Saric, Tripti Singh, Christie M. Bartels, Shivani Garg   +5 more
wiley   +1 more source

Efficient reverse saturable absorption of sol-gel hybrid plasmonic glasses

, 2017
International audienceMonolithic silica sol-gel glasses doped with platinum(II) acetylide complexes possessing respectively four or six phenylacetylene units (PE2-CH2OH and PE3-CH2OH) in combination with various concentrations of spherical and ...
Chaput, F., Liotta, A., Lundén, H.,, Lerouge, F., Parola, S., Chateau,, D.,, C. Lopes, Chaput,, F.,, Lerouge,, F.,, D. Chateau, A. Désert, Lundén, H., M. Lindgren, Lopes, Cesar,, F. Chaput, Désert,, A.,, A. Liotta, Parola,, S.,, H. Lundén, F. Lerouge, Liotta, A.,, Lindgren, M., Lopes, C., S. Parola, Lindgren, Mikael,, Chateau, D., Désert, A.   +26 more
core   +1 more source

Karl Popper and the Mechanisms of Hydrogen Embrittlement

Advanced Engineering Materials, EarlyView.
Representation of the beginning of loss of ductility rather than embrittlement. Small concentrations of hydrogen in a diffusible form within iron are well‐established to harm the mechanical integrity of steels. There are theories that attempt to explain the pernicious role of hydrogen.
H. K. D. H. Bhadeshia
wiley   +1 more source

Nonlinear optical behaviour of bis (cytosinium) tartarate monohydrate single crystal

Chemical Physics Impact, 2022
A nonlinear optical single crystal of bis (cytosinium) tartarate monohydrate (BCTM) was grown by slow evaporation method at room temperature. Single crystal X-ray diffraction study revealed their cell parameters and corresponding space group.
P. Jaikumar, T. Balakrishnan, C. Indumathi, T.C. Sabari Girisun, K. Ramamurthi   +4 more
doaj   +1 more source

Comparison of Triply Periodic Minimal Surface Energy Absorbers Under Uniaxial Compressive Loading

Advanced Engineering Materials, EarlyView.
This study investigates LCD 3D printed Triply Periodic Minimal Surface (TPMS) structures as mechanical energy absorbers. By comparing various base designs and layered combinations under uniaxial compression, it identifies that a Diamond‐Gyroid sandwich structure offers superior performance.
Sergej Grednev, Noah‐Lean Roschlaub, Anne Jung   +2 more
wiley   +1 more source

Influence of Si Content and Milling Duration on the Microstructure and Mechanical–Tribological Properties of AlCoCrFeNiSi High‐Entropy Alloys

Advanced Engineering Materials, EarlyView.
Si‐doped AlCoCrFeNi high‐entropy alloys are synthesized by mechanical alloying to reveal the effect of Si content and milling time on phase evolution, microstructural refinement, and tribological behavior. A transition from FCC to BCC structure, significant grain refinement, and enhanced hardness and wear resistance are achieved, with the 4 at% Si ...
Mustafa Okumuş, Mehmet Emin Demir, Sercan Özpınar   +2 more
wiley   +1 more source

Biomass Native Structure Into Functional Carbon‐Based Catalysts for Fenton‐Like Reactions

Advanced Functional Materials, EarlyView.
This study indicates that eight biomasses with 2D flaky and 1D acicular structures influence surface O types, morphology, defects, N doping, sp2 C, and Co nanoparticles loading in three series of carbon, N‐doped carbon, and cobalt/graphitic carbon. This work identifies how these structural factors impact catalytic pathways, enhancing selective electron
Wenjie Tian, Jingkai Lin, Zhihao Tian, Selusiwe Ncube, Huayang Zhang, Emiliano Cortés, Hongqi Sun, Shaobin Wang   +7 more
wiley   +1 more source

Two-wavelength, dual regime Q-switched erbium-doped fiber laser based on a microfiber loop coated with gold nanostars as the saturable absorber

Results in Optics
We report a two-wavelength, dual-regime Q-switched erbium-doped fiber laser employing a microfiber loop coated with gold nanostars as the saturable absorber.
A. Martinez-Rios, G. Anzueto-Sanchez, J.L. Pichardo-Molina, L.F. Enriquez-Gomez, R.E. Nuñez-Gomez, L.A. Rodriguez-Morales, O. Pottiez, A. Kir’yanov   +7 more
doaj   +1 more source

Exploring Curvature Effects in Direct‐Written 3D Curved Hollow Magnetic Nanoshells

Advanced Functional Materials, EarlyView.
Fabricated by a hybrid FEBID/CVD method, 3D PtC/Co3Fe core–shell heterostructures with engineered curvature and shell thickness exhibit complex reversal modes with axially symmetric N'eel‐type domain walls. XMCD‐PEEM combined with full‐scale micromagnetic simulations reveal how curvature and thickness govern the domain wall energy landscape and shape ...
Oleksii M. Volkov, Fabrizio Porrati, Florian Kronast, Riccardo Hertel, Pavlo Makushko, Olha Bezsmertna, Alexander Kuprava, Mohamad‐Assaad Mawass, Sven Barth, Michael Huth, Denys Makarov   +10 more
wiley   +1 more source