Results 121 to 130 of about 273,066 (341)

Versican splice variant messenger RNA expression in normal human Achilles tendon and tendinopathies [PDF]

, 2004
Versican is the principal large proteoglycan expressed in mid-tendon, but its role in tendon pathology is unknown. Our objective was to define the expression of versican isoform splice variant messenger ribonucleic acid (mRNA) in normal Achilles tendons,
Corps, AN, Costa, ML, Hazleman, BL, Ireland, DC, Movin, T, Riley, GP, Robinson, AHN   +6 more
core   +2 more sources

AP2M1 Amplification Orchestrates Notch‐Mediated Chemoresistance in Hematopoietic Stem Cells of Acute Myeloid Leukemia Patients

Advanced Science, EarlyView.
The precise regulation of AP2M1 is essential for normal hematopoiesis. Overexpression of AP2M1 negatively affects the clinical outcomes of AML patients. Upregulation of AP2M1 enhances stemness and chemoresistance in HSPC cells of AML. AP2M1 modulates NOTCH1 expression, enhancing the Notch1 signaling pathway.
Hansong Lee, Eun Kyoung Kim, Hee Young Ju, Chae Rin Lee, Soyul Ahn, Eun‐Sun Kim, Kyungjae Myung, Won Kyu Kim, Su‐Yeon Cho, Yujin Kwon, Dokyoung Kim, Yeuni Yu, Eun Jung Kwon, Hyomin Kim, Seong Ik Mun, Dong Min Lim, Kihun Kim, Hye Jin Heo, Seung Eun Baek, Sun Young Lee, Hyunsoo Cho, Eun Young Choi, Tae Sik Goh, Ninib Baryawno, Dongjun Lee, Ki Sun Jung, Keon Hee Yoo, Chang‐Kyu Oh, Yun Hak Kim   +28 more
wiley   +1 more source

Immunological assays for chemokine detection in in-vitro culture of CNS cells

Biological Procedures Online, 2003
Herein we review the various methods currently in use for determining the expression of chemokines by CNS cells in vitro. Chemokine detection assays are used in conjuction with one another to provide a comprehensive, biologically relevant assessment of ...
Mahajan Supriya D., Schwartz Stanley A., Nair Madhavan P.N.   +2 more
doaj   +1 more source

Light Metabolically Reprograms CD8+ T Cells to Potentiate STING‐Driven Tumor Eradication and Prevent Metastasis

Advanced Science, EarlyView.
Low‐level light (LLL) rejuvenates exhausted CD8+ T cells, boosting STING‐driven tumor eradication and prevents metastasis. NanoSTING@Mn enhances CD8+ T cells infiltration while LLL restores its function expanding to progenitor‐exhausted cells. These cells form central memory T cells in lymphoid organs. Intranasal nanoSTING@Mn redirects antitumor CD8+ T
Asmita Banstola, Shilin Gao, Zhengkung Zhang, Yan Dong, Prabhat Upadhyay, Quanwei Zhang, Yongli Li, Zuan‐Tao Lin, Zhilong Wang, Mei X. Wu   +9 more
wiley   +1 more source

Detection of calicivirus from fecal samples from children with acute gastroenteritis in the West Central region of Brazil

Memorias do Instituto Oswaldo Cruz, 2006
The objective of this study was to describe the circulation of caliciviruses in the West Central region of Brazil and its correlation with children's gender and age, as well as with the year and months of the sample collection.
Ana Maria Tavares Borges, José Marcus Sócrates Teixeira, Paulo Sérgio Sucasas da Costa, Loreny Gimenes Giugliano, Fabíola Souza Fiaccadori, Rachel de Carvalho e Franco, Wilia Marta Elsner Diederichsen de Brito, José Paulo Gagliardi Leite, Divina das Dores de Paula Cardoso   +8 more
doaj   +1 more source

Short communication: optimization of semi-quantitative RT PCR analysis for CPT I gene expression in rainbow trout (Oncorhynchus mykiss) [PDF]

, 2011
A key enzyme in mitochondrial β¬oxidation, carnitine palmitoyltransferase (CPT) I, is transcriptionally regulated in mammals, but this enzyme also experiences allosteric modulations (Harano et al., 1985; Murthy and Pande, 1987; Bezaire et al., 2004). CPT
Jalali, S.A.H., Jalali, S.M.A., Mahboobi Soofiani, N., Nikbakht, G.   +3 more
core  

Interleukin 31 mediates MAP kinase and STAT1/3 activation in intestinal epithelial cells and its expression is upregulated in inflammatory bowel disease [PDF]

, 2007
Background/aim: Interleukin 31 (IL31), primarily expressed in activated lymphocytes, signals through a heterodimeric receptor complex consisting of the IL31 receptor alpha (IL31R\textgreeka) and the oncostatin M receptor (OSMR). The aim of this study was
Auernhammer, Christoph J., Beigel, Florian, Brand, Stephan, Dambacher, Julia, Göke, Burkhard, Haller, Dirk, Seiderer, Julia   +6 more
core   +2 more sources

Osmotically Tunable Microdroplets Enable Amplification‐Free CRISPR Detection of Gene Doping

Advanced Science, EarlyView.
A novel amplification‐free clustered regularly interspaced short palindromic repeats/CRISPR‐associated protein (CRISPR/Cas) 12a assay is integrated with osmotically shrinkable double emulsion droplets for the rapid and ultrasensitive detection of gene doping.
Jihun Han, Reya Ganguly, Joon‐Yeop Yi, Hyewon Yun, So‐Yeon Jung, Changmin Sung, Chang‐Soo Lee   +6 more
wiley   +1 more source

Cadherin‐26 Facilitates Transepithelial Migration of Eosinophils in Eosinophilic Chronic Rhinosinusitis

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Eosinophilic chronic rhinosinusitis with nasal polyps (eCRSwNP) is characterized by persistent sinonasal inflammation and marked eosinophilic infiltration. Although the relationship between eosinophils and NP formation has been extensively studied, the mechanisms governing eosinophil transepithelial migration into the nasal mucosa ...
Yeong‐In Jo, Jee Won Moon, Joo‐Hoo Park, Hwa Eun Yang, Subin Cho, Hyeongguk Son, Hyun‐Woo Yang, Il‐Ho Park   +7 more
wiley   +1 more source

Laboratory Diagnosis of Mumps in a Partially Immunized Population: The Nova Scotia Experience

Canadian Journal of Infectious Diseases and Medical Microbiology, 2009
BACKGROUND: In 2007, Atlantic Canada experienced a large outbreak of mumps predominately in university students who had received a single dose of measles, mumps and rubella vaccine.
TF Hatchette, R Davidson, S Clay, J Pettipas, J LeBlanc, S Sarwal, M Smieja, KR Forward   +7 more
doaj   +1 more source