Reverse-transcriptase polymerase chain reaction versus chest computed tomography for detecting early symptoms of COVID-19. A diagnostic accuracy systematic review and meta-analysis. [PDF]
Duarte ML+5 more
europepmc +1 more source
Past, present, and future strategies for detecting and quantifying circular RNA variants
Originally considered artifact of RNA splicing, over 3 million circular RNAs have been found in humans alone through a combination of ultrasensitive detection methods and bespoke bioinformatics tools. This review covers past, present, and future strategies for detecting and quantifying circular RNAs and how they are illuminating novel circular RNA ...
He Lin, Vanessa M. Conn, Simon J. Conn
wiley +1 more source
Underperformance of Reverse-Transcriptase Polymerase Chain Reaction in Japan and Potential Implications From Diamond Princess Cruise Ship and Other Countries During the Ongoing COVID-19 Pandemic. [PDF]
Yamamoto K+6 more
europepmc +1 more source
Human tissue kallikrein 14 (KLK14), a skin protease, may mediate paracrine signaling in wound healing. KLK14 released by epithelial cells activates fibroblasts via PAR‐1 activation, inducing IL‐6, IL‐8, and CXCL1 expression. These cytokines in turn promote keratinocyte proliferation and migration, resulting in wound closure.
Laura Sasiadek+16 more
wiley +1 more source
False-positive reverse transcriptase polymerase chain reaction screening for SARS-CoV-2 in the setting of urgent head and neck surgery and otolaryngologic emergencies during the pandemic: Clinical implications. [PDF]
Katz AP+10 more
europepmc +1 more source
Gle1 knockout mice fail to segregate cell lineages at the blastocyst stage, resulting in very early embryonic lethality. Gle1 knock‐in (KI) mice harboring a pathogenic variant giving rise to lethal congenital contracture syndrome 1 show both known and novel innervation defects, supportive of multiorgan pathology in human fetuses.
Tomáš Zárybnický+22 more
wiley +1 more source
Th2 mRNA gene expression analysis separates Prurigo nodularis into two immune signature groups
Protein expression, histology and RNA analyses were performed from patients with prurigo nodularis (PN). All patients had typical PN characteristics. Lymphocytes/monocytes demonstrated more frequent positive staining signals in lesional versus non‐lesional samples for IL‐31, IL‐31RA, OSM and OSMRb.
Sonja Ständer+20 more
wiley +1 more source
Abstract Sexual maturation of male Atlantic salmon post‐smolts (‘jacking’) is undesired in aquaculture and seems to occur due to the intensification in modern facilities. Maturation depends on internal and external factors (temperature, photoperiod, feed availability, energy levels, body size, genetic background) that act on the brain‐pituitary‐gonad ...
Enrique Pino‐Martinez+5 more
wiley +1 more source